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• W2747527165 endingPage "e0182530" @default.
• W2747527165 startingPage "e0182530" @default.
• W2747527165 abstract "Changing light conditions, caused by the rotation of earth resulting in day and night or growth on the surface or within a substrate, result in considerably altered physiological processes in fungi. For the biotechnological workhorse Trichoderma reesei, regulation of glycoside hydrolase gene expression, especially cellulase expression was shown to be a target of light dependent gene regulation. Analysis of regulatory targets of the carbon catabolite repressor CRE1 under cellulase inducing conditions revealed a secondary metabolite cluster to be differentially regulated in light and darkness and by photoreceptors. We found that this cluster is involved in production of trichodimerol and that the two polyketide synthases of the cluster are essential for biosynthesis of dihydrotrichotetronine (syn. bislongiquinolide or bisorbibutenolide). Additionally, an indirect influence on production of the peptaibol antibiotic paracelsin was observed. The two polyketide synthetase genes as well as the monooxygenase gene of the cluster were found to be connected at the level of transcription in a positive feedback cycle in darkness, but negative feedback in light, indicating a cellular sensing and response mechanism for the products of these enzymes. The transcription factor TR_102497/YPR2 residing within the cluster regulates the cluster genes in a light dependent manner. Additionally, an interrelationship of this cluster with regulation of cellulase gene expression was detected. Hence the regulatory connection between primary and secondary metabolism appears more widespread than previously assumed, indicating a sophisticated distribution of resources either to degradation of substrate (feed) or to antagonism of competitors (fight), which is influenced by light." @default.
• W2747527165 created "2017-08-31" @default.
• W2747527165 creator A5003978738 @default.
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• W2747527165 date "2017-08-15" @default.
• W2747527165 modified "2023-10-17" @default.
• W2747527165 title "A CRE1- regulated cluster is responsible for light dependent production of dihydrotrichotetronin in Trichoderma reesei" @default.
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• W2747527165 doi "https://doi.org/10.1371/journal.pone.0182530" @default.
• W2747527165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5557485" @default.
• W2747527165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28809958" @default.
• W2747527165 hasPublicationYear "2017" @default.
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