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• W2747528201 abstract "Abstract Gastrointestinal malignancies have been a tremendous problem in the medical field and cover a wide variety of parts of the system, (i.e. esophagus, duodenum, intestines, and rectum). Usually, these malignancies are treated with palliation with the use of non-vascular nitinol stents. However, stenting is not a perfect solution for these problems. While it can enhance the quality of life of the patient, in time the device will encounter problems such as re-occlusion due to the rapid growth of the tumor. In this study, we propose a functionalization technique using electropolymerization of polydopamine directly onto the nitinol stent struts for the combined application of hyperthermia and chemotherapy. The coating was characterized using FESEM, XPS, and FT-IR. Drug release studies show that facile release of the anticancer drug BTZ from the surface of the polydopamine-coated stent could be achieved by the dissociation between catechol groups of polydopamine and the boronic acid functionality of BTZ in a pH-dependent manner. The anti-cancer property was also evaluated, and cytotoxicity on ESO26 and SNU-5 cancer cell lines were observed. Our results suggest that the introduced approach can be considered as a potential method for therapeutic stent application." @default.
• W2747528201 created "2017-08-31" @default.
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• W2747528201 date "2017-08-25" @default.
• W2747528201 modified "2023-10-16" @default.
• W2747528201 title "Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy" @default.
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• W2747528201 doi "https://doi.org/10.1038/s41598-017-08833-x" @default.
• W2747528201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5573377" @default.
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• W2747528201 hasPublicationYear "2017" @default.
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