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- W2747580487 endingPage "1029" @default.
- W2747580487 startingPage "1016" @default.
- W2747580487 abstract "Coordinatively saturated ruthenium complexes with a variable net charge are currently under intense investigation for their anticancer potential. These complexes, possessing long wavelength metal-to-ligand charge transfer with DNA photonuclease activity, have shown promising cytotoxic profiles. Although most of the ruthenium complexes exhibit significant photochemotherapeutic activity, their poor entry into cells hinder their development as potential drug molecules. Here, we report the synthesis and characterization of four new ruthenium (II) azo-8-hydroxyquinoline complexes, their mode of in vitro DNA binding and antiproliferative properties against cultured human cancer cell lines. The activity of these compounds prior to photoirradiation is minimal. However, they could induce DNA photonuclease activity through the generation of reactive oxygen species upon exposure to light. The activities exhibited by these complexes were found to be more efficient (>5-fold) than cisplatin, emphasizing their therapeutic potential. Collectively, these results support the idea that ruthenium (II) azo-8-hydroxyquinoline complexes can serve as potential agents in photodynamic anticancer therapy." @default.
- W2747580487 created "2017-08-31" @default.
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- W2747580487 creator A5090701117 @default.
- W2747580487 date "2017-10-01" @default.
- W2747580487 modified "2023-09-26" @default.
- W2747580487 title "Novel ruthenium azo-quinoline complexes with enhanced photonuclease activity in human cancer cells" @default.
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- W2747580487 doi "https://doi.org/10.1016/j.ejmech.2017.08.059" @default.
- W2747580487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28910739" @default.
- W2747580487 hasPublicationYear "2017" @default.
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