FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747609436> ?p ?o ?g. }

• W2747609436 endingPage "691" @default.
• W2747609436 startingPage "687" @default.
• W2747609436 abstract "ObjectiveTo investigate the association between RhoA and cardiomyopathy in type 2 diabetic rats and the intervention effect of fasudil.MethodsThe type 2 diabetic SD rat models were established by feeding with high-fat, high-sucrose diet and intraperitoneal injection of low-dose streptozotocin (30 mg/kg). The type 2 diabetic rats (n=30) were randomly divided into two groups: diabetic group (n=15) and fasudil group (n=15). In addition, 10 SD rats were set as normal control. The rats in fasudil group received fasudil at a dosage of 10 mg · kg-1· d-1 by intraperitoneal injection for 4 weeks. The rats in diabetic group and control group were given injection of saline simultaneously. At the end of the study, the weight of heart was measured and the heart/body weight index (HWI) was calculated. The histological changes in left ventricle were observed by light microscope and electron microscope. The protein and mRNA expression of RhoA in myocardium were examined by immunohistochemistry staining and reverse transcription-polymerase chain reaction (RT-PCR), respectively. The comparison of data between the groups were done with t or t' test.ResultsHWI of diabetic group was higher than that of control group(0.006 0± 0.000 4 vs 0.003 0±0.000 3, t=-21.121, P=0.005). HWI of fasudil group(0.005 0±0.000 4) was lower than that of diabetic group(t=4.523, P=0.008). The histological changes of myocardium in diabetic group were severe and changes of those in fasudil group were moderate. The protein expression of RhoA in the diabetic group (70±10) was 2.89 times of that in the control group (24±3), and it was (53±6) in fasudil group. The expression level of RhoA mRNA in diabetic group was significantly higher than that in control group (1.43± 0.16 vs 0.42±0.06, t=-33.437, P=0.012). And the expression of RhoA mRNA in fasudil group (0.73±0.13) was significantly lower than that in diabetic group(t=8.145, P=0.038). The expression level of RhoA protein and mRNA were both positively correlated with HWI(r=0.94, 0.85, both P<0.05).ConclusionsRhoA involves in the pathogenesis and progression of diabetic cardiomyopathy. Fasudil protects the diabetic myocardium by lowering the expression of RhoA.Key words: Diabetes mellitus, type 2; Diabetic cardiomyopathy; Fasudil; RhoA" @default.
• W2747609436 created "2017-08-31" @default.
• W2747609436 creator A5015611534 @default.
• W2747609436 creator A5057871819 @default.
• W2747609436 date "2016-11-27" @default.
• W2747609436 modified "2023-09-28" @default.
• W2747609436 title "Association between RhoA and cardiomyopathy in type 2 diabetic rats and the intervention of fasudil" @default.
• W2747609436 doi "https://doi.org/10.3760/cma.j.issn.1674-5809.2016.11.011" @default.
• W2747609436 hasPublicationYear "2016" @default.
• W2747609436 type Work @default.
• W2747609436 sameAs 2747609436 @default.
• W2747609436 citedByCount "0" @default.
• W2747609436 crossrefType "journal-article" @default.
• W2747609436 hasAuthorship W2747609436A5015611534 @default.
• W2747609436 hasAuthorship W2747609436A5057871819 @default.
• W2747609436 hasConcept C126322002 @default.
• W2747609436 hasConcept C134018914 @default.
• W2747609436 hasConcept C185592680 @default.
• W2747609436 hasConcept C201800478 @default.
• W2747609436 hasConcept C2776048814 @default.
• W2747609436 hasConcept C2776553924 @default.
• W2747609436 hasConcept C2777093181 @default.
• W2747609436 hasConcept C2778198053 @default.
• W2747609436 hasConcept C2778797674 @default.
• W2747609436 hasConcept C2778921608 @default.
• W2747609436 hasConcept C2779280383 @default.
• W2747609436 hasConcept C2780159080 @default.
• W2747609436 hasConcept C55493867 @default.
• W2747609436 hasConcept C555293320 @default.
• W2747609436 hasConcept C62478195 @default.
• W2747609436 hasConcept C71924100 @default.
• W2747609436 hasConceptScore W2747609436C126322002 @default.
• W2747609436 hasConceptScore W2747609436C134018914 @default.
• W2747609436 hasConceptScore W2747609436C185592680 @default.
• W2747609436 hasConceptScore W2747609436C201800478 @default.
• W2747609436 hasConceptScore W2747609436C2776048814 @default.
• W2747609436 hasConceptScore W2747609436C2776553924 @default.
• W2747609436 hasConceptScore W2747609436C2777093181 @default.
• W2747609436 hasConceptScore W2747609436C2778198053 @default.
• W2747609436 hasConceptScore W2747609436C2778797674 @default.
• W2747609436 hasConceptScore W2747609436C2778921608 @default.
• W2747609436 hasConceptScore W2747609436C2779280383 @default.
• W2747609436 hasConceptScore W2747609436C2780159080 @default.
• W2747609436 hasConceptScore W2747609436C55493867 @default.
• W2747609436 hasConceptScore W2747609436C555293320 @default.
• W2747609436 hasConceptScore W2747609436C62478195 @default.
• W2747609436 hasConceptScore W2747609436C71924100 @default.
• W2747609436 hasIssue "11" @default.
• W2747609436 hasLocation W27476094361 @default.
• W2747609436 hasOpenAccess W2747609436 @default.
• W2747609436 hasPrimaryLocation W27476094361 @default.
• W2747609436 hasRelatedWork W1992958562 @default.
• W2747609436 hasRelatedWork W1996816319 @default.
• W2747609436 hasRelatedWork W2054820240 @default.
• W2747609436 hasRelatedWork W2325003405 @default.
• W2747609436 hasRelatedWork W2354579802 @default.
• W2747609436 hasRelatedWork W2359962350 @default.
• W2747609436 hasRelatedWork W2360687181 @default.
• W2747609436 hasRelatedWork W2365363215 @default.
• W2747609436 hasRelatedWork W2365451833 @default.
• W2747609436 hasRelatedWork W2366839496 @default.
• W2747609436 hasRelatedWork W2379329722 @default.
• W2747609436 hasRelatedWork W2385533863 @default.
• W2747609436 hasRelatedWork W2387636729 @default.
• W2747609436 hasRelatedWork W2388428067 @default.
• W2747609436 hasRelatedWork W2391886446 @default.
• W2747609436 hasRelatedWork W2429007244 @default.
• W2747609436 hasRelatedWork W2623941441 @default.
• W2747609436 hasRelatedWork W2751269627 @default.
• W2747609436 hasRelatedWork W3029546907 @default.
• W2747609436 hasRelatedWork W3032534243 @default.
• W2747609436 hasVolume "8" @default.
• W2747609436 isParatext "false" @default.
• W2747609436 isRetracted "false" @default.
• W2747609436 magId "2747609436" @default.
• W2747609436 workType "article" @default.