Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747717833> ?p ?o ?g. }
- W2747717833 endingPage "1233" @default.
- W2747717833 startingPage "1225" @default.
- W2747717833 abstract "Purpose To present a time-to-failure (TTF) analysis for all patients treated with permanent interstitial brachytherapy (PIB) at our institution, with additional analyses to correlate successful reirradiation and to identify the frequency of severe grade 3 to 4 toxicity. Methods and Materials Forty-two previously irradiated patients received curative or palliative intent PIB for a recurrent pelvic malignancy between January 2009 and August 2016. Minimum follow-up was 6 months after the PIB procedure. All patients had a biopsy-proven recurrence and were treated using PIB alone (n=32) or in combination with a short course of additional radiation therapy (n=10). Competing risk analyses were performed to assess the risk of failures in the presence of death without failure. Exploratory analyses were performed for factors related to failure using competing risk analyses and the Gray statistic. Results A total of 61 PIB implants were performed among 42 patients with a median follow-up of 16.3 months. Fifty-two implants were performed as the first salvage reirradiation to a solitary recurrence (8 patients had more than 1 lesion); the success rate for initial reirradiation using PIB was 73% (38 cases out of 52), and the median TTF was not reached. Nine patients underwent a second repeat PIB to the same recurrence as a form of salvage; 3 (33%) remain without evidence of recurrence. The median TTF after second salvage was 7.7 months. Even with the limited sample size, prolonged TTF was marginally associated with definitive intent (P=.07) and the extent of disease at the time of PIB (P=.08). Grade 3+ toxicities were seen in 8 patients (16.7%). Conclusions Permanent interstitial brachytherapy is a feasible and potentially durable treatment modality that can be used to curatively salvage selected recurrent pelvic malignancies in a previously irradiated field. To present a time-to-failure (TTF) analysis for all patients treated with permanent interstitial brachytherapy (PIB) at our institution, with additional analyses to correlate successful reirradiation and to identify the frequency of severe grade 3 to 4 toxicity. Forty-two previously irradiated patients received curative or palliative intent PIB for a recurrent pelvic malignancy between January 2009 and August 2016. Minimum follow-up was 6 months after the PIB procedure. All patients had a biopsy-proven recurrence and were treated using PIB alone (n=32) or in combination with a short course of additional radiation therapy (n=10). Competing risk analyses were performed to assess the risk of failures in the presence of death without failure. Exploratory analyses were performed for factors related to failure using competing risk analyses and the Gray statistic. A total of 61 PIB implants were performed among 42 patients with a median follow-up of 16.3 months. Fifty-two implants were performed as the first salvage reirradiation to a solitary recurrence (8 patients had more than 1 lesion); the success rate for initial reirradiation using PIB was 73% (38 cases out of 52), and the median TTF was not reached. Nine patients underwent a second repeat PIB to the same recurrence as a form of salvage; 3 (33%) remain without evidence of recurrence. The median TTF after second salvage was 7.7 months. Even with the limited sample size, prolonged TTF was marginally associated with definitive intent (P=.07) and the extent of disease at the time of PIB (P=.08). Grade 3+ toxicities were seen in 8 patients (16.7%). Permanent interstitial brachytherapy is a feasible and potentially durable treatment modality that can be used to curatively salvage selected recurrent pelvic malignancies in a previously irradiated field." @default.
- W2747717833 created "2017-08-31" @default.
- W2747717833 creator A5009589088 @default.
- W2747717833 creator A5018306130 @default.
- W2747717833 creator A5063075025 @default.
- W2747717833 creator A5070862168 @default.
- W2747717833 creator A5072199362 @default.
- W2747717833 creator A5078208818 @default.
- W2747717833 creator A5081279720 @default.
- W2747717833 date "2017-12-01" @default.
- W2747717833 modified "2023-09-26" @default.
- W2747717833 title "Reirradiation Using Permanent Interstitial Brachytherapy: A Potentially Durable Technique for Salvaging Recurrent Pelvic Malignancies" @default.
- W2747717833 cites W1969984572 @default.
- W2747717833 cites W1984915241 @default.
- W2747717833 cites W1987350137 @default.
- W2747717833 cites W1992555964 @default.
- W2747717833 cites W1997466005 @default.
- W2747717833 cites W1999735836 @default.
- W2747717833 cites W2007404624 @default.
- W2747717833 cites W2007683352 @default.
- W2747717833 cites W2019139619 @default.
- W2747717833 cites W2028588553 @default.
- W2747717833 cites W2033561507 @default.
- W2747717833 cites W2035909006 @default.
- W2747717833 cites W2048740182 @default.
- W2747717833 cites W2065331468 @default.
- W2747717833 cites W2066875006 @default.
- W2747717833 cites W2069351071 @default.
- W2747717833 cites W2072246662 @default.
- W2747717833 cites W2074277582 @default.
- W2747717833 cites W2078879168 @default.
- W2747717833 cites W2079509225 @default.
- W2747717833 cites W2082347836 @default.
- W2747717833 cites W2100756525 @default.
- W2747717833 cites W2101667461 @default.
- W2747717833 cites W2112624449 @default.
- W2747717833 cites W2118098858 @default.
- W2747717833 cites W2129906542 @default.
- W2747717833 cites W2140833524 @default.
- W2747717833 cites W2156402187 @default.
- W2747717833 cites W2157168791 @default.
- W2747717833 cites W2162603883 @default.
- W2747717833 cites W2170552969 @default.
- W2747717833 cites W2568344630 @default.
- W2747717833 cites W2579943566 @default.
- W2747717833 cites W4237928820 @default.
- W2747717833 cites W4246219232 @default.
- W2747717833 cites W4376453253 @default.
- W2747717833 doi "https://doi.org/10.1016/j.ijrobp.2017.08.027" @default.
- W2747717833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29029888" @default.
- W2747717833 hasPublicationYear "2017" @default.
- W2747717833 type Work @default.
- W2747717833 sameAs 2747717833 @default.
- W2747717833 citedByCount "17" @default.
- W2747717833 countsByYear W27477178332017 @default.
- W2747717833 countsByYear W27477178332018 @default.
- W2747717833 countsByYear W27477178332019 @default.
- W2747717833 countsByYear W27477178332020 @default.
- W2747717833 countsByYear W27477178332021 @default.
- W2747717833 countsByYear W27477178332022 @default.
- W2747717833 crossrefType "journal-article" @default.
- W2747717833 hasAuthorship W2747717833A5009589088 @default.
- W2747717833 hasAuthorship W2747717833A5018306130 @default.
- W2747717833 hasAuthorship W2747717833A5063075025 @default.
- W2747717833 hasAuthorship W2747717833A5070862168 @default.
- W2747717833 hasAuthorship W2747717833A5072199362 @default.
- W2747717833 hasAuthorship W2747717833A5078208818 @default.
- W2747717833 hasAuthorship W2747717833A5081279720 @default.
- W2747717833 hasConcept C126322002 @default.
- W2747717833 hasConcept C126838900 @default.
- W2747717833 hasConcept C141071460 @default.
- W2747717833 hasConcept C2775934546 @default.
- W2747717833 hasConcept C2776694085 @default.
- W2747717833 hasConcept C2777416452 @default.
- W2747717833 hasConcept C2779399171 @default.
- W2747717833 hasConcept C2780775027 @default.
- W2747717833 hasConcept C509974204 @default.
- W2747717833 hasConcept C71924100 @default.
- W2747717833 hasConceptScore W2747717833C126322002 @default.
- W2747717833 hasConceptScore W2747717833C126838900 @default.
- W2747717833 hasConceptScore W2747717833C141071460 @default.
- W2747717833 hasConceptScore W2747717833C2775934546 @default.
- W2747717833 hasConceptScore W2747717833C2776694085 @default.
- W2747717833 hasConceptScore W2747717833C2777416452 @default.
- W2747717833 hasConceptScore W2747717833C2779399171 @default.
- W2747717833 hasConceptScore W2747717833C2780775027 @default.
- W2747717833 hasConceptScore W2747717833C509974204 @default.
- W2747717833 hasConceptScore W2747717833C71924100 @default.
- W2747717833 hasIssue "5" @default.
- W2747717833 hasLocation W27477178331 @default.
- W2747717833 hasLocation W27477178332 @default.
- W2747717833 hasOpenAccess W2747717833 @default.
- W2747717833 hasPrimaryLocation W27477178331 @default.
- W2747717833 hasRelatedWork W1511885230 @default.
- W2747717833 hasRelatedWork W1897659454 @default.
- W2747717833 hasRelatedWork W2057841679 @default.
- W2747717833 hasRelatedWork W2066252593 @default.
- W2747717833 hasRelatedWork W2412780601 @default.