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- W2747770801 abstract "Ewing sarcoma (EWS) is a highly aggressive and metabolically active malignant tumor. Metabolic activity can broadly be characterized by features of glycolytic activity and oxidative phosphorylation. We have further characterized metabolic features of EWS cells to identify potential therapeutic targets. EWS cells had significantly more glycolytic activity compared to their non-malignant counterparts. Thus, metabolic inhibitors of glycolysis such as 2-deoxy-D-glucose (2DG) and of the mitochondrial respiratory pathway, such as metformin, were evaluated as potential therapeutic agents against a panel of EWS cell lines in vitro. Results indicate that 2DG alone or in combination with metformin was effective at inducing cell death in EWS cell lines. The predominant mechanism of cell death appears to be through stimulating apoptosis leading into necrosis with concomitant activation of AMPK-α. Furthermore, we demonstrate that the use of metabolic modulators can target putative EWS stem cells, both in vitro and in vivo, and potentially overcome chemotherapeutic resistance in EWS. Based on these data, clinical strategies using drugs targeting tumor cell metabolism present a viable therapeutic modality against EWS." @default.
- W2747770801 created "2017-08-31" @default.
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- W2747770801 date "2017-08-24" @default.
- W2747770801 modified "2023-10-16" @default.
- W2747770801 title "Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties" @default.
- W2747770801 cites W143172746 @default.
- W2747770801 cites W1536070820 @default.
- W2747770801 cites W1565979608 @default.
- W2747770801 cites W1603973942 @default.
- W2747770801 cites W1789215739 @default.
- W2747770801 cites W1793366630 @default.
- W2747770801 cites W1876426852 @default.
- W2747770801 cites W1966339676 @default.
- W2747770801 cites W1967245224 @default.
- W2747770801 cites W1986543208 @default.
- W2747770801 cites W1989483924 @default.
- W2747770801 cites W1992381541 @default.
- W2747770801 cites W1994731715 @default.
- W2747770801 cites W1995069275 @default.
- W2747770801 cites W1995745247 @default.
- W2747770801 cites W1997909566 @default.
- W2747770801 cites W1998196049 @default.
- W2747770801 cites W2000098894 @default.
- W2747770801 cites W2007624262 @default.
- W2747770801 cites W2011575938 @default.
- W2747770801 cites W2011659954 @default.
- W2747770801 cites W2020993937 @default.
- W2747770801 cites W2021117623 @default.
- W2747770801 cites W2022983661 @default.
- W2747770801 cites W2023316892 @default.
- W2747770801 cites W2028303721 @default.
- W2747770801 cites W2041094651 @default.
- W2747770801 cites W2056537433 @default.
- W2747770801 cites W2056724848 @default.
- W2747770801 cites W2059623168 @default.
- W2747770801 cites W2068798216 @default.
- W2747770801 cites W2072315137 @default.
- W2747770801 cites W2072909107 @default.
- W2747770801 cites W2080654617 @default.
- W2747770801 cites W2088232413 @default.
- W2747770801 cites W2093778789 @default.
- W2747770801 cites W2099616702 @default.
- W2747770801 cites W2102322990 @default.
- W2747770801 cites W2103758698 @default.
- W2747770801 cites W2105010528 @default.
- W2747770801 cites W2107030585 @default.
- W2747770801 cites W2116319147 @default.
- W2747770801 cites W2117692326 @default.
- W2747770801 cites W2118829872 @default.
- W2747770801 cites W2125747634 @default.
- W2747770801 cites W2125789330 @default.
- W2747770801 cites W2126701448 @default.
- W2747770801 cites W2126812050 @default.
- W2747770801 cites W2131719921 @default.
- W2747770801 cites W2134907909 @default.
- W2747770801 cites W2135943905 @default.
- W2747770801 cites W2140164776 @default.
- W2747770801 cites W2143681046 @default.
- W2747770801 cites W2144847112 @default.
- W2747770801 cites W2146654374 @default.
- W2747770801 cites W2146780639 @default.
- W2747770801 cites W2146904663 @default.
- W2747770801 cites W2148755064 @default.
- W2747770801 cites W2150419930 @default.
- W2747770801 cites W2153227626 @default.
- W2747770801 cites W2154285890 @default.
- W2747770801 cites W2154643246 @default.
- W2747770801 cites W2158240289 @default.
- W2747770801 cites W2159194061 @default.
- W2747770801 cites W2164559547 @default.
- W2747770801 cites W2164937682 @default.
- W2747770801 cites W2167414381 @default.
- W2747770801 cites W2167872282 @default.
- W2747770801 cites W2171979623 @default.
- W2747770801 cites W2226316051 @default.
- W2747770801 cites W2302398359 @default.
- W2747770801 cites W2583138401 @default.
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- W2747770801 doi "https://doi.org/10.18632/oncotarget.20467" @default.
- W2747770801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5652780" @default.
- W2747770801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29100387" @default.
- W2747770801 hasPublicationYear "2017" @default.
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