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• W2747787806 abstract "Abstract Mental disorders are one of the leading causes of disability globally. Inherited genetic variation in pharmacokinetic (PK) and pharmacodynamic (PD) genes may contribute to the observed interindividual differences in clinical efficacy and tolerability of psychopharmaceuticals. Therefore, strategies for improving effectiveness of pharmacological treatments translating pharmacogenomic information from bench to clinic have been recently attempted. However, effectiveness of available psychiatric pharmacogenomic tools in ameliorating clinical symptoms has not been analyzed in populations of suitable size by means of adequately powered multicentric randomized clinical trials. The Neuropharmagen personalized medicine platform integrates pharmacogenomic data from the analysis of PK and PD genes to provide actionable recommendations for psychoactive drugs, including genotype-specific dose adjustments and the risk of specific adverse effects based on FDA-approved drug labelling, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines, and meta-analyses of clinical studies. Moreover, within the Neuropharmagen platform, pharmacogenomic recommendations can be complemented combined with alerts on drug-drug, drug-clinical condition and drug-environmental factor interactions. Notably, the later can be updated by the doctor whenever there are changes in the condition of the patient or the pharmacological treatment. Clinical efficacy of the Neuropharmagen test has been evaluated in two multicentric clinical studies totaling 462 patients analyzed for the primary outcome at study endpoint. A retrospective study evaluating patients with different psychiatric diagnoses and at least 1 treatment failure found that patients whose treatment followed the pharmacogenetic (PGx) test recommendations had odds of improvement about 4 times higher than patients whose treatment did not (adjusted OR = 3.86, 95%CI 1.36–10.95; p = 0.011). Recently, we have completed a prospective randomized clinical trial conducted in 316 patients with major depressive disorder with a wide range of depression severities and number of treatment failures. In this talk, I will describe the main results of both studies, with a major focus in those obtained in the multicentric randomized clinical trial. Overall, the combined results of studies conducted with Neuropharmagen show that PGx-guided treatment constitutes a significant tool to improve clinical response and medication tolerability, especially in subjects with moderate to severe depression and in those with previous failed drug trials." @default.
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• W2747787806 date "2017-01-01" @default.
• W2747787806 modified "2023-10-18" @default.
• W2747787806 title "Pharmacogenomic Information In The Treatment Of Major Depression: Results From A Randomized Clinical Trial" @default.
• W2747787806 doi "https://doi.org/10.1016/j.euroneuro.2016.09.388" @default.
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