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• W2747823845 abstract "Sickness is typically characterized by fever, anorexia, cachexia, and reductions in social, pleasurable, and sexual behaviors. These responses can be displayed at varying intensities both within and among individuals, and the adaptive nature of sickness responses can be demonstrated by the context-dependent nature of their expression. The study of sickness has become an important area of investigation for researchers in a wide range of areas, including psychoneuroimmunology (PNI) and ecoimmunology (EI). The general goal of PNI is to identify key interactions among the nervous, endocrine and immune systems and behavior, and how disruptions in these processes might contribute to disease states. EI, in turn, has been established more recently within the perspectives of ecology and evolutionary biology, and is aimed more at understanding natural variation in immune function and sickness responses within a broadly integrative, organismal, and evolutionary context. The goal of this review is to examine the literature on sickness from both basic and biomedical perspectives within PNI and EI and to demonstrate how the integrative study of sickness behavior can serve as an integrating agent to connect ecological and translational approaches to the study of disease. By focusing on a set of specific exemplars, including the energetics of sickness, social context, and environmental influences on sickness, we hope to accomplish the larger goal of developing a common synthetic framework to understand sickness from multiple levels of analysis and varying perspectives across the fields of PNI and EI. By applying this integrative approach to sickness, we will be able to develop a more comprehensive view of sickness as a suite of adaptive responses rather than the simply deleterious consequences of illness." @default.
• W2747823845 created "2017-08-31" @default.
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• W2747823845 date "2017-08-25" @default.
• W2747823845 modified "2023-10-13" @default.
• W2747823845 title "A Return to Wisdom: Using Sickness Behaviors to Integrate Ecological and Translational Research" @default.
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• W2747823845 doi "https://doi.org/10.1093/icb/icx051" @default.
• W2747823845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5886345" @default.
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• W2747823845 hasPublicationYear "2017" @default.
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