FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747881429> ?p ?o ?g. }

• W2747881429 endingPage "20170470" @default.
• W2747881429 startingPage "20170470" @default.
• W2747881429 abstract "Curcumin is a plant secondary metabolite with outstanding therapeutic effects. Therefore, there is a great interest in developing new strategies to produce this high-value compound in a cheaper and environmentally friendly way. Curcumin heterologous production in Escherichia coli using artificial biosynthetic pathways was previously demonstrated using synthetic biology approaches. However, the culturing conditions to produce this compound were not optimized and so far only a two-step fermentation process involving the exchange of culture medium allowed high concentrations of curcumin to be obtained, which limits its production at an industrial scale. In this study, the culturing conditions to produce curcumin were evaluated and optimized. In addition, it was concluded that E. coli BL21 allows higher concentrations of curcumin to be produced than E. coli K-12 strains. Different isopropyl β- d -thiogalactopyranoside concentrations, time of protein expression induction and substrate type and concentration were also evaluated. The highest curcumin production obtained was 959.3 µM (95.93% of per cent yield), which was 3.1-fold higher than the highest concentration previously reported. This concentration was obtained using a two-stage fermentation with lysogeny broth (LB) and M9. Moreover, terrific broth was also demonstrated to be a very interesting alternative medium to produce curcumin because it also led to high concentrations (817.7 µM). The use of this single fermentation medium represents an advantage at industrial scale and, although the final production is lower than that obtained with the LB–M9 combination, it leads to a significantly higher production of curcumin in the first 24 h of fermentation. This study allowed obtaining the highest concentrations of curcumin reported so far in a heterologous organism and is of interest for all of those working with the heterologous production of curcuminoids, other complex polyphenolic compounds or plant secondary metabolites." @default.
• W2747881429 created "2017-08-31" @default.
• W2747881429 creator A5010103352 @default.
• W2747881429 creator A5021667092 @default.
• W2747881429 creator A5028714626 @default.
• W2747881429 date "2017-08-01" @default.
• W2747881429 modified "2023-10-16" @default.
• W2747881429 title "Optimization of fermentation conditions for the production of curcumin by engineered <i>Escherichia coli</i>" @default.
• W2747881429 cites W1599600334 @default.
• W2747881429 cites W1942591007 @default.
• W2747881429 cites W1966688774 @default.
• W2747881429 cites W1967084994 @default.
• W2747881429 cites W1970762019 @default.
• W2747881429 cites W1972486342 @default.
• W2747881429 cites W1975998834 @default.
• W2747881429 cites W1981471795 @default.
• W2747881429 cites W2002025633 @default.
• W2747881429 cites W2024172008 @default.
• W2747881429 cites W2056057107 @default.
• W2747881429 cites W2065885744 @default.
• W2747881429 cites W2066492436 @default.
• W2747881429 cites W2074147805 @default.
• W2747881429 cites W2077378005 @default.
• W2747881429 cites W2081902722 @default.
• W2747881429 cites W2083315765 @default.
• W2747881429 cites W2083727216 @default.
• W2747881429 cites W2099196052 @default.
• W2747881429 cites W2100950596 @default.
• W2747881429 cites W2101896194 @default.
• W2747881429 cites W2103340429 @default.
• W2747881429 cites W2103947911 @default.
• W2747881429 cites W2118290033 @default.
• W2747881429 cites W2118645907 @default.
• W2747881429 cites W2119714707 @default.
• W2747881429 cites W2126472213 @default.
• W2747881429 cites W2138820253 @default.
• W2747881429 cites W2140443201 @default.
• W2747881429 cites W2145786570 @default.
• W2747881429 cites W2146394143 @default.
• W2747881429 cites W2166374078 @default.
• W2747881429 cites W2261551157 @default.
• W2747881429 cites W2344472570 @default.
• W2747881429 cites W2417502812 @default.
• W2747881429 cites W2503407456 @default.
• W2747881429 cites W2522813771 @default.
• W2747881429 cites W2618420209 @default.
• W2747881429 cites W2620248703 @default.
• W2747881429 doi "https://doi.org/10.1098/rsif.2017.0470" @default.
• W2747881429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5582133" @default.
• W2747881429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28835544" @default.
• W2747881429 hasPublicationYear "2017" @default.
• W2747881429 type Work @default.
• W2747881429 sameAs 2747881429 @default.
• W2747881429 citedByCount "32" @default.
• W2747881429 countsByYear W27478814292017 @default.
• W2747881429 countsByYear W27478814292018 @default.
• W2747881429 countsByYear W27478814292019 @default.
• W2747881429 countsByYear W27478814292020 @default.
• W2747881429 countsByYear W27478814292021 @default.
• W2747881429 countsByYear W27478814292022 @default.
• W2747881429 countsByYear W27478814292023 @default.
• W2747881429 crossrefType "journal-article" @default.
• W2747881429 hasAuthorship W2747881429A5010103352 @default.
• W2747881429 hasAuthorship W2747881429A5021667092 @default.
• W2747881429 hasAuthorship W2747881429A5028714626 @default.
• W2747881429 hasBestOaLocation W27478814291 @default.
• W2747881429 hasConcept C100544194 @default.
• W2747881429 hasConcept C104317684 @default.
• W2747881429 hasConcept C185592680 @default.
• W2747881429 hasConcept C2777477808 @default.
• W2747881429 hasConcept C2778250585 @default.
• W2747881429 hasConcept C2779039970 @default.
• W2747881429 hasConcept C31903555 @default.
• W2747881429 hasConcept C547475151 @default.
• W2747881429 hasConcept C55493867 @default.
• W2747881429 hasConcept C73401843 @default.
• W2747881429 hasConceptScore W2747881429C100544194 @default.
• W2747881429 hasConceptScore W2747881429C104317684 @default.
• W2747881429 hasConceptScore W2747881429C185592680 @default.
• W2747881429 hasConceptScore W2747881429C2777477808 @default.
• W2747881429 hasConceptScore W2747881429C2778250585 @default.
• W2747881429 hasConceptScore W2747881429C2779039970 @default.
• W2747881429 hasConceptScore W2747881429C31903555 @default.
• W2747881429 hasConceptScore W2747881429C547475151 @default.
• W2747881429 hasConceptScore W2747881429C55493867 @default.
• W2747881429 hasConceptScore W2747881429C73401843 @default.
• W2747881429 hasFunder F4320334779 @default.
• W2747881429 hasFunder F4320335322 @default.
• W2747881429 hasIssue "133" @default.
• W2747881429 hasLocation W27478814291 @default.
• W2747881429 hasLocation W27478814292 @default.
• W2747881429 hasLocation W27478814293 @default.
• W2747881429 hasLocation W27478814294 @default.
• W2747881429 hasLocation W27478814295 @default.
• W2747881429 hasOpenAccess W2747881429 @default.
• W2747881429 hasPrimaryLocation W27478814291 @default.
• W2747881429 hasRelatedWork W2023371964 @default.
• W2747881429 hasRelatedWork W2258914008 @default.

• next