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- W2747921809 abstract "Hematopoietic stem cells (HSCs) reside in the bone marrow niche. HSC behaviour is regulated through interaction of signalling molecules produced by the niche and HSCs themselves. In this dissertation, the role of the secreted molecule Wnt5a in terms of hematopoiesis and leukemia was investigated. The loss of one allele of the Wnt5a gene has an enormous effect on the primitive hematopoiesis in vivo. Wnt5a in the bone marrow niche is essential for the maintenance of hematopoietic stem cells as well as leukemic stem cells. It could be shown that extrinsic Wnt5a level affect the onset of hematologic disease and is required for the development of leukemia-initiating cells." @default.
- W2747921809 created "2017-08-31" @default.
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- W2747921809 date "2015-01-01" @default.
- W2747921809 modified "2023-09-27" @default.
- W2747921809 title "The role of Wnt5a in hematopoiesis and leukemia" @default.
- W2747921809 hasPublicationYear "2015" @default.
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