Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747949429> ?p ?o ?g. }
- W2747949429 endingPage "6599" @default.
- W2747949429 startingPage "6587" @default.
- W2747949429 abstract "The crotonases comprise a widely distributed enzyme superfamily that has multiple roles in both primary and secondary metabolism. Many crotonases employ oxyanion hole-mediated stabilization of intermediates to catalyze the reaction of coenzyme A (CoA) thioester substrates (e.g., malonyl-CoA, α,β-unsaturated CoA esters) both with nucleophiles and, in the case of enolate intermediates, with varied electrophiles. Reactions of crotonases that proceed via a stabilized oxyanion intermediate include the hydrolysis of substrates including proteins, as well as hydration, isomerization, nucleophilic aromatic substitution, Claisen-type, and cofactor-independent oxidation reactions. The crotonases have a conserved fold formed from a central β-sheet core surrounded by α-helices, which typically oligomerizes to form a trimer or dimer of trimers. The presence of a common structural platform and mechanisms involving intermediates with diverse reactivity implies that crotonases have considerable potential for biocatalysis and synthetic biology, as supported by pioneering protein engineering studies on them. In this Perspective, we give an overview of crotonase diversity and structural biology and then illustrate the scope of crotonase catalysis and potential for biocatalysis." @default.
- W2747949429 created "2017-08-31" @default.
- W2747949429 creator A5037368498 @default.
- W2747949429 creator A5042398293 @default.
- W2747949429 creator A5045067042 @default.
- W2747949429 creator A5052664019 @default.
- W2747949429 creator A5054947792 @default.
- W2747949429 date "2017-08-31" @default.
- W2747949429 modified "2023-09-24" @default.
- W2747949429 title "Crotonases: Nature’s Exceedingly Convertible Catalysts" @default.
- W2747949429 cites W1485824567 @default.
- W2747949429 cites W1533138158 @default.
- W2747949429 cites W1576708451 @default.
- W2747949429 cites W1883093314 @default.
- W2747949429 cites W1952433052 @default.
- W2747949429 cites W1955032465 @default.
- W2747949429 cites W1956158739 @default.
- W2747949429 cites W1965737130 @default.
- W2747949429 cites W1966158819 @default.
- W2747949429 cites W1967316786 @default.
- W2747949429 cites W1968373874 @default.
- W2747949429 cites W1970253946 @default.
- W2747949429 cites W1976064081 @default.
- W2747949429 cites W1984180361 @default.
- W2747949429 cites W1987370810 @default.
- W2747949429 cites W1987489902 @default.
- W2747949429 cites W1993909514 @default.
- W2747949429 cites W1997333596 @default.
- W2747949429 cites W1998351916 @default.
- W2747949429 cites W1999077520 @default.
- W2747949429 cites W1999949134 @default.
- W2747949429 cites W2002431007 @default.
- W2747949429 cites W2002637334 @default.
- W2747949429 cites W2005635502 @default.
- W2747949429 cites W2007486805 @default.
- W2747949429 cites W2009667649 @default.
- W2747949429 cites W2009674285 @default.
- W2747949429 cites W2010813390 @default.
- W2747949429 cites W2012892422 @default.
- W2747949429 cites W2015657441 @default.
- W2747949429 cites W2016676863 @default.
- W2747949429 cites W2017674401 @default.
- W2747949429 cites W2018075301 @default.
- W2747949429 cites W2019155664 @default.
- W2747949429 cites W2030092354 @default.
- W2747949429 cites W2033708403 @default.
- W2747949429 cites W2038408290 @default.
- W2747949429 cites W2041008580 @default.
- W2747949429 cites W2050097392 @default.
- W2747949429 cites W2053822489 @default.
- W2747949429 cites W2054897207 @default.
- W2747949429 cites W2055890190 @default.
- W2747949429 cites W2057376120 @default.
- W2747949429 cites W2057499903 @default.
- W2747949429 cites W2075676398 @default.
- W2747949429 cites W2080024283 @default.
- W2747949429 cites W2080146018 @default.
- W2747949429 cites W2081594548 @default.
- W2747949429 cites W2083634445 @default.
- W2747949429 cites W2089766135 @default.
- W2747949429 cites W2090190937 @default.
- W2747949429 cites W2090905687 @default.
- W2747949429 cites W2092719284 @default.
- W2747949429 cites W2092762680 @default.
- W2747949429 cites W2093561820 @default.
- W2747949429 cites W2095562247 @default.
- W2747949429 cites W2096514720 @default.
- W2747949429 cites W2097238178 @default.
- W2747949429 cites W2097444598 @default.
- W2747949429 cites W2097745167 @default.
- W2747949429 cites W2102136647 @default.
- W2747949429 cites W2106396528 @default.
- W2747949429 cites W2109065365 @default.
- W2747949429 cites W2113561798 @default.
- W2747949429 cites W2116520861 @default.
- W2747949429 cites W2123743784 @default.
- W2747949429 cites W2125873032 @default.
- W2747949429 cites W2128305572 @default.
- W2747949429 cites W2129892461 @default.
- W2747949429 cites W2131681747 @default.
- W2747949429 cites W2145571109 @default.
- W2747949429 cites W2148752303 @default.
- W2747949429 cites W2154678978 @default.
- W2747949429 cites W2159056434 @default.
- W2747949429 cites W2159675211 @default.
- W2747949429 cites W2163747193 @default.
- W2747949429 cites W2170960986 @default.
- W2747949429 cites W2219863195 @default.
- W2747949429 cites W2230538333 @default.
- W2747949429 cites W2313684425 @default.
- W2747949429 cites W2316797042 @default.
- W2747949429 cites W2506996763 @default.
- W2747949429 cites W2557496587 @default.
- W2747949429 cites W2564766938 @default.
- W2747949429 cites W2607147441 @default.
- W2747949429 cites W2731426204 @default.
- W2747949429 cites W4231117458 @default.
- W2747949429 cites W4249584358 @default.