Matches in SemOpenAlex for { <https://semopenalex.org/work/W2747996954> ?p ?o ?g. }
- W2747996954 endingPage "312" @default.
- W2747996954 startingPage "302" @default.
- W2747996954 abstract "Chronic intestinal inflammation is a risk factor for colorectal cancer (CRC) initiation and development. Diets that are rich in Western style fats have been shown to promote CRC. This study was conducted to investigate the role of intestinal microbiome in American ginseng-mediated CRC chemoprevention in a mouse model. The population and diversity of enteric microbiome were evaluated after the ginseng treatment. Using an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced gut inflammation and tumorigenesis mouse model, the effects of oral American ginseng on high fat diet-associated enteric pathology were determined. After establishment of a 16S rRNA illumina library from fecal samples, MiSeq sequencing was carried out to reveal the microbial population. The alpha and beta diversities of microbiome were analyzed. American ginseng significantly attenuated AOM/DSS-induced colon inflammation and tumorigenesis by reducing the colitis score and colon tumor multiplicity. The MiSeq results showed that the majority of sequences fell into three phyla: Firmicutes, Bacteroidetes and Verrucomicrobia. Further, two significant abundance shifts at the family level, Bacteroidaceae and Porphyromonadaceae, were identified to support ginseng’s anti-colitis and anti-tumor effects. In addition, alpha and beta diversity data demonstrated that ginseng led to a profound recovery from the AOM/DSS-induced dysbiosis in the microbial community. Our results suggest that the CRC chemopreventive effects of American ginseng are mediated through enteric microbiome population-shift recovery and dysbiosis restoration. Ginseng’s regulation of the microbiome balance contributes to the maintenance of enteric homeostasis." @default.
- W2747996954 created "2017-08-31" @default.
- W2747996954 creator A5009403989 @default.
- W2747996954 creator A5010211752 @default.
- W2747996954 creator A5015271282 @default.
- W2747996954 creator A5020423570 @default.
- W2747996954 creator A5042231260 @default.
- W2747996954 creator A5042917596 @default.
- W2747996954 creator A5048988670 @default.
- W2747996954 creator A5061465995 @default.
- W2747996954 creator A5061500406 @default.
- W2747996954 creator A5070578608 @default.
- W2747996954 creator A5075669369 @default.
- W2747996954 creator A5082562345 @default.
- W2747996954 date "2017-08-14" @default.
- W2747996954 modified "2023-10-17" @default.
- W2747996954 title "Role of intestinal microbiome in American ginseng-mediated colon cancer protection in high fat diet-fed AOM/DSS mice" @default.
- W2747996954 cites W1967482627 @default.
- W2747996954 cites W1975714310 @default.
- W2747996954 cites W1978138839 @default.
- W2747996954 cites W1988912601 @default.
- W2747996954 cites W1998252427 @default.
- W2747996954 cites W2023339504 @default.
- W2747996954 cites W2041341409 @default.
- W2747996954 cites W2047847066 @default.
- W2747996954 cites W2079527932 @default.
- W2747996954 cites W2096224929 @default.
- W2747996954 cites W2110235509 @default.
- W2747996954 cites W2118727180 @default.
- W2747996954 cites W2120707725 @default.
- W2747996954 cites W2143360088 @default.
- W2747996954 cites W2148395963 @default.
- W2747996954 cites W2153178471 @default.
- W2747996954 cites W2158626993 @default.
- W2747996954 cites W2167474785 @default.
- W2747996954 cites W2168682720 @default.
- W2747996954 cites W2274284262 @default.
- W2747996954 cites W2278830266 @default.
- W2747996954 cites W2310707027 @default.
- W2747996954 cites W2314413252 @default.
- W2747996954 cites W2321587877 @default.
- W2747996954 cites W2328023807 @default.
- W2747996954 cites W2344233709 @default.
- W2747996954 cites W2520657669 @default.
- W2747996954 cites W2520972989 @default.
- W2747996954 cites W2556836231 @default.
- W2747996954 cites W2564393024 @default.
- W2747996954 cites W2594373254 @default.
- W2747996954 doi "https://doi.org/10.1007/s12094-017-1717-z" @default.
- W2747996954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5812846" @default.
- W2747996954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28808878" @default.
- W2747996954 hasPublicationYear "2017" @default.
- W2747996954 type Work @default.
- W2747996954 sameAs 2747996954 @default.
- W2747996954 citedByCount "31" @default.
- W2747996954 countsByYear W27479969542018 @default.
- W2747996954 countsByYear W27479969542019 @default.
- W2747996954 countsByYear W27479969542020 @default.
- W2747996954 countsByYear W27479969542021 @default.
- W2747996954 countsByYear W27479969542022 @default.
- W2747996954 countsByYear W27479969542023 @default.
- W2747996954 crossrefType "journal-article" @default.
- W2747996954 hasAuthorship W2747996954A5009403989 @default.
- W2747996954 hasAuthorship W2747996954A5010211752 @default.
- W2747996954 hasAuthorship W2747996954A5015271282 @default.
- W2747996954 hasAuthorship W2747996954A5020423570 @default.
- W2747996954 hasAuthorship W2747996954A5042231260 @default.
- W2747996954 hasAuthorship W2747996954A5042917596 @default.
- W2747996954 hasAuthorship W2747996954A5048988670 @default.
- W2747996954 hasAuthorship W2747996954A5061465995 @default.
- W2747996954 hasAuthorship W2747996954A5061500406 @default.
- W2747996954 hasAuthorship W2747996954A5070578608 @default.
- W2747996954 hasAuthorship W2747996954A5075669369 @default.
- W2747996954 hasAuthorship W2747996954A5082562345 @default.
- W2747996954 hasBestOaLocation W27479969542 @default.
- W2747996954 hasConcept C121608353 @default.
- W2747996954 hasConcept C126322002 @default.
- W2747996954 hasConcept C142724271 @default.
- W2747996954 hasConcept C143121216 @default.
- W2747996954 hasConcept C203014093 @default.
- W2747996954 hasConcept C204787440 @default.
- W2747996954 hasConcept C2775862500 @default.
- W2747996954 hasConcept C2777165150 @default.
- W2747996954 hasConcept C2778148229 @default.
- W2747996954 hasConcept C2778452354 @default.
- W2747996954 hasConcept C2779232237 @default.
- W2747996954 hasConcept C2908647359 @default.
- W2747996954 hasConcept C526805850 @default.
- W2747996954 hasConcept C539455810 @default.
- W2747996954 hasConcept C60644358 @default.
- W2747996954 hasConcept C71924100 @default.
- W2747996954 hasConcept C86803240 @default.
- W2747996954 hasConcept C90924648 @default.
- W2747996954 hasConcept C99454951 @default.
- W2747996954 hasConceptScore W2747996954C121608353 @default.
- W2747996954 hasConceptScore W2747996954C126322002 @default.
- W2747996954 hasConceptScore W2747996954C142724271 @default.
- W2747996954 hasConceptScore W2747996954C143121216 @default.