FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2748016656> ?p ?o ?g. }

• W2748016656 endingPage "541" @default.
• W2748016656 startingPage "535" @default.
• W2748016656 abstract "Oxidative stress may contribute to the development of chronic pancreatitis (CP). The enzymes manganese superoxide dismutase 2 (MnSOD, SOD2) and catalase (CAT) counteract free radical activity within the mitochondria and the cytosol. Moreover, CAT activity contributes to the transformation of ethanol to acetaldehyde, a toxic intermediate product of ethanol metabolism, which has been associated with pancreatic damage. Common functional polymorphisms have been described in the MnSOD gene [rs4880, NM_000636.3:c.47 T > C, alanine (ALA) to valine (Val)] and in the CAT promoter region [rs1001179, NG_013339.1:g.4760 C > T]. We investigated whether these polymorphisms are associated with alcoholic CP. We genotyped 470 patients with alcoholic CP for these MnSOD and CAT polymorphisms. We also analysed these variants in 357 healthy control subjects, and in an additional control group of 113 individuals with non-alcoholic CP. We used the age at onset of CP as marker of disease severity and investigated whether different genotypes are associated with different ages at onset. In patients with alcoholic CP, we investigated whether an interaction exists between smoking behaviour and genotypes by comparing genotype distributions in smokers and non-smokers. We did not observe significant differences of genotype frequencies between patient groups and controls. In patient groups, we did not find significant differences in the ages at onset between different genotypes. We did not observe an interaction between these polymorphisms. We did not find an association of these variants with smoking behaviour. The investigated MnSOD and CAT polymorphisms do not predispose to the development of alcoholic CP. Patients with alcoholic pancreatitis and controls were genotyped for polymorphisms in oxidative stress genes. There were no significant differences of genotype frequencies between patients and controls, and no association with the age at onset of disease was observed. The polymorphisms are not associated with the development of alcoholic pancreatitis." @default.
• W2748016656 created "2017-08-31" @default.
• W2748016656 creator A5002673746 @default.
• W2748016656 creator A5014209447 @default.
• W2748016656 creator A5015732555 @default.
• W2748016656 creator A5017674652 @default.
• W2748016656 creator A5041394329 @default.
• W2748016656 creator A5042517469 @default.
• W2748016656 creator A5055291545 @default.
• W2748016656 creator A5056862255 @default.
• W2748016656 creator A5068147172 @default.
• W2748016656 creator A5072669534 @default.
• W2748016656 creator A5079986408 @default.
• W2748016656 date "2017-06-26" @default.
• W2748016656 modified "2023-10-17" @default.
• W2748016656 title "Genetic Variants in the Manganese Superoxide Dismutase 2 Gene and in the Catalase Gene are not Associated With Alcoholic Chronic Pancreatitis" @default.
• W2748016656 cites W1578896628 @default.
• W2748016656 cites W1708326960 @default.
• W2748016656 cites W1965188580 @default.
• W2748016656 cites W1969210030 @default.
• W2748016656 cites W1972790402 @default.
• W2748016656 cites W1978328971 @default.
• W2748016656 cites W1988837230 @default.
• W2748016656 cites W1990319295 @default.
• W2748016656 cites W2033588110 @default.
• W2748016656 cites W2035027225 @default.
• W2748016656 cites W2035858790 @default.
• W2748016656 cites W2042935911 @default.
• W2748016656 cites W2044494908 @default.
• W2748016656 cites W2056005329 @default.
• W2748016656 cites W2072157296 @default.
• W2748016656 cites W2074717002 @default.
• W2748016656 cites W2081339715 @default.
• W2748016656 cites W2085396235 @default.
• W2748016656 cites W2086100865 @default.
• W2748016656 cites W2091693945 @default.
• W2748016656 cites W2094023492 @default.
• W2748016656 cites W2110804723 @default.
• W2748016656 cites W2116419479 @default.
• W2748016656 cites W2123098050 @default.
• W2748016656 cites W2135298606 @default.
• W2748016656 cites W2143414809 @default.
• W2748016656 cites W2157798820 @default.
• W2748016656 cites W2161179012 @default.
• W2748016656 cites W2161569099 @default.
• W2748016656 cites W2291203412 @default.
• W2748016656 cites W2292139095 @default.
• W2748016656 cites W3093943070 @default.
• W2748016656 cites W4230164866 @default.
• W2748016656 cites W4232765264 @default.
• W2748016656 cites W4237857420 @default.
• W2748016656 doi "https://doi.org/10.1093/alcalc/agx039" @default.
• W2748016656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28655148" @default.
• W2748016656 hasPublicationYear "2017" @default.
• W2748016656 type Work @default.
• W2748016656 sameAs 2748016656 @default.
• W2748016656 citedByCount "0" @default.
• W2748016656 crossrefType "journal-article" @default.
• W2748016656 hasAuthorship W2748016656A5002673746 @default.
• W2748016656 hasAuthorship W2748016656A5014209447 @default.
• W2748016656 hasAuthorship W2748016656A5015732555 @default.
• W2748016656 hasAuthorship W2748016656A5017674652 @default.
• W2748016656 hasAuthorship W2748016656A5041394329 @default.
• W2748016656 hasAuthorship W2748016656A5042517469 @default.
• W2748016656 hasAuthorship W2748016656A5055291545 @default.
• W2748016656 hasAuthorship W2748016656A5056862255 @default.
• W2748016656 hasAuthorship W2748016656A5068147172 @default.
• W2748016656 hasAuthorship W2748016656A5072669534 @default.
• W2748016656 hasAuthorship W2748016656A5079986408 @default.
• W2748016656 hasBestOaLocation W27480166561 @default.
• W2748016656 hasConcept C104317684 @default.
• W2748016656 hasConcept C126322002 @default.
• W2748016656 hasConcept C134018914 @default.
• W2748016656 hasConcept C135763542 @default.
• W2748016656 hasConcept C2775838275 @default.
• W2748016656 hasConcept C2775967933 @default.
• W2748016656 hasConcept C2776108821 @default.
• W2748016656 hasConcept C2776151105 @default.
• W2748016656 hasConcept C2777214474 @default.
• W2748016656 hasConcept C2777575235 @default.
• W2748016656 hasConcept C2777595113 @default.
• W2748016656 hasConcept C2778979269 @default.
• W2748016656 hasConcept C2780161600 @default.
• W2748016656 hasConcept C54355233 @default.
• W2748016656 hasConcept C55493867 @default.
• W2748016656 hasConcept C71924100 @default.
• W2748016656 hasConcept C86803240 @default.
• W2748016656 hasConceptScore W2748016656C104317684 @default.
• W2748016656 hasConceptScore W2748016656C126322002 @default.
• W2748016656 hasConceptScore W2748016656C134018914 @default.
• W2748016656 hasConceptScore W2748016656C135763542 @default.
• W2748016656 hasConceptScore W2748016656C2775838275 @default.
• W2748016656 hasConceptScore W2748016656C2775967933 @default.
• W2748016656 hasConceptScore W2748016656C2776108821 @default.
• W2748016656 hasConceptScore W2748016656C2776151105 @default.
• W2748016656 hasConceptScore W2748016656C2777214474 @default.
• W2748016656 hasConceptScore W2748016656C2777575235 @default.
• W2748016656 hasConceptScore W2748016656C2777595113 @default.

• next