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- W2748178192 abstract "Mevalonate (MVA) is a key compound of living organisms including bacteria, plants, and humans. MVA and mevalonolactone (MVL), a lactonized form of MVA, are important for pharmaceutical, cosmeceutical, and biotechnological applications. Although (R, S)-MVA with 50% enantiomeric purity is mainly produced by chemical synthesis, recently, microbial fermentation processes for MVA production have been considered as an alternative to the chemical synthesis because of high enantiomeric purity [(R)-MVA] and high titer. In the present study, bio-MVA produced by a fermentative process was decolorized by a charcoal-based method and then chemically transformed into bio-MVL without byproducts by means of phosphoric acid as an acid catalyst. The final bio-MVL was (R)-MVL with over 99% enantiomeric purity according to 1H NMR analysis." @default.
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- W2748178192 date "2017-10-01" @default.
- W2748178192 modified "2023-10-12" @default.
- W2748178192 title "Purification of biomevalonate from fermentation broth and conversion of biomevalonate into biomevalonolactone" @default.
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- W2748178192 doi "https://doi.org/10.1016/j.jbiotec.2017.08.017" @default.
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