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- W274820822 abstract "Inositol 1,4,5-trisphosphate (IP{sub 3}), an intracellular messenger, releases Ca{sup 2+} from microsomes. Ca{sup 2+} plays a major role in regulating various cellular events like neural transmission and regulation of hormones and growth factors. Aluminium (Al), Lead (Pb) and Mercury (Hg) were reported to alter Ca{sup 2+}-regulated events thereby causing neurotoxicity. Hence, the authors made an attempt to characterize IP{sub 3} mediated Ca{sup 2+} release from rat brain microsomes under the influence of Al, Pb and Hg. Different concentrations of metals were taken over a period of time and their effects on IP{sub 3} mediated Ca{sup 2+} release from microsomes were monitored using fura-2 technique. All the three metals were found to inhibit IP{sub 3} mediated Ca{sup 2+} release in a concentration dependent manner, Pb being more potent. The order of potency of these three metals was Pb > Hg > Al. Except for Al, both Hg and Pb independently released Ca{sup 2+} from microsomes. Uptake of Ca{sup 2+} into the microsomes was also inhibited by all the three metals, Hg being more potent. A 100% inhibition of Ca{sup 2+} uptake was observed with 10 {mu}M of Hg, and a 50% inhibition of Ca{sup 2+} uptake was observed with 0.5 andmore » 80{mu}M of Pb and Al respectively. These results suggest that neurotoxicity exerted by Al,Pb and Hg may be due to the interference of these metals with IP{sub 3} mediated Ca{sup 2+} release.« less" @default.
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- W274820822 date "1991-03-11" @default.
- W274820822 modified "2023-09-27" @default.
- W274820822 title "Differential effects of aluminium, lead and mercury on inositol 1,4,5-trisphosphate mediated Ca sup 2+ release from rat brain microsomes" @default.
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