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- W2748217844 abstract "Glioblastoma is an immunosuppressive, fatal brain cancer that contains glioblastoma stem-like cells (GSCs). Oncolytic herpes simplex virus (oHSV) selectively replicates in cancer cells while inducing anti-tumor immunity. oHSV G47Δ expressing murine IL-12 (G47Δ-mIL12), antibodies to immune checkpoints (CTLA-4, PD-1, PD-L1), or dual combinations modestly extended survival of a mouse glioma model. However, the triple combination of anti-CTLA-4, anti-PD-1, and G47Δ-mIL12 cured most mice in two glioma models. This treatment was associated with macrophage influx and M1-like polarization, along with increased T effector to T regulatory cell ratios. Immune cell depletion studies demonstrated that CD4+ and CD8+ T cells as well as macrophages are required for synergistic curative activity. This combination should be translatable to the clinic and other immunosuppressive cancers." @default.
- W2748217844 created "2017-08-31" @default.
- W2748217844 creator A5057638091 @default.
- W2748217844 creator A5059949459 @default.
- W2748217844 creator A5065492142 @default.
- W2748217844 date "2017-08-01" @default.
- W2748217844 modified "2023-10-17" @default.
- W2748217844 title "Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade" @default.
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- W2748217844 cites W1881296535 @default.
- W2748217844 cites W1881610795 @default.
- W2748217844 cites W1902577542 @default.
- W2748217844 cites W1921451985 @default.
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- W2748217844 cites W1980485314 @default.
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- W2748217844 cites W2033577259 @default.
- W2748217844 cites W2036341107 @default.
- W2748217844 cites W2037044453 @default.
- W2748217844 cites W2037378061 @default.
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- W2748217844 doi "https://doi.org/10.1016/j.ccell.2017.07.006" @default.
- W2748217844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5568814" @default.
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- W2748217844 hasPublicationYear "2017" @default.
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