FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2748244778> ?p ?o ?g. }

• W2748244778 endingPage "991" @default.
• W2748244778 startingPage "977" @default.
• W2748244778 abstract "Introduction: Fibroblast activation protein-α (FAP-α) belongs to the family of prolyl-specific serine proteases. FAP-α displays both exopeptidase and endopeptidase/gelatinase/collagenase activities. FAP-α protein and/or activity have been associated with fibrosis, inflammation and cancer, but the protein is undetectable in most normal tissues. FAP-α is selectively expressed at sites of tissue remodeling and repair and enhances tumor progression, suggesting that this protease may be a therapeutic target to treat human disorders associated with fibrotic dysregulation.Areas covered: In this review, we summarize the mechanisms driving tissue fibrosis and describe some of the enzymes involved in fibrosis, concentrating on FAP-α. We describe its enzymatic properties, discuss the tools developed to control its activity and the problem of selectivity toward the other proteases of the family and outline its potential biological substrates. We also consider non-enzymatic functions of this protein and suggest that repression of FAP-α expression may represent therapeutic options.Expert opinion: Questions remain regarding the biological functions of FAP-α, either dependent or independent of its enzyme activity. However, as progress is underway to develop FAP-α-specific inhibitors and therapeutic antibodies, its role in diseases associated with fibrosis is starting to emerge, ultimately leading to novel therapeutic options for inflammatory and oncologic diseases." @default.
• W2748244778 created "2017-08-31" @default.
• W2748244778 creator A5026172020 @default.
• W2748244778 creator A5045591440 @default.
• W2748244778 creator A5087387177 @default.
• W2748244778 date "2017-08-30" @default.
• W2748244778 modified "2023-10-18" @default.
• W2748244778 title "Fibroblast activation protein-α in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?" @default.
• W2748244778 cites W123872733 @default.
• W2748244778 cites W140440376 @default.
• W2748244778 cites W1515429739 @default.
• W2748244778 cites W1518396628 @default.
• W2748244778 cites W1533538364 @default.
• W2748244778 cites W1545804167 @default.
• W2748244778 cites W1550669392 @default.
• W2748244778 cites W1553821695 @default.
• W2748244778 cites W1569752535 @default.
• W2748244778 cites W1577118500 @default.
• W2748244778 cites W1734472624 @default.
• W2748244778 cites W1764151989 @default.
• W2748244778 cites W1809059557 @default.
• W2748244778 cites W1824834086 @default.
• W2748244778 cites W1905956901 @default.
• W2748244778 cites W1910308666 @default.
• W2748244778 cites W1931670291 @default.
• W2748244778 cites W1949956414 @default.
• W2748244778 cites W1962268158 @default.
• W2748244778 cites W1963684724 @default.
• W2748244778 cites W1963758313 @default.
• W2748244778 cites W1963941872 @default.
• W2748244778 cites W1970326193 @default.
• W2748244778 cites W1974411204 @default.
• W2748244778 cites W1975016799 @default.
• W2748244778 cites W1975987306 @default.
• W2748244778 cites W1977437151 @default.
• W2748244778 cites W1980724829 @default.
• W2748244778 cites W1982811673 @default.
• W2748244778 cites W1983097616 @default.
• W2748244778 cites W1984243890 @default.
• W2748244778 cites W1990393931 @default.
• W2748244778 cites W1991669931 @default.
• W2748244778 cites W1991883406 @default.
• W2748244778 cites W1992592944 @default.
• W2748244778 cites W1994174156 @default.
• W2748244778 cites W1994793426 @default.
• W2748244778 cites W1997593976 @default.
• W2748244778 cites W1999597218 @default.
• W2748244778 cites W2000290970 @default.
• W2748244778 cites W2002145465 @default.
• W2748244778 cites W2002457691 @default.
• W2748244778 cites W2002689409 @default.
• W2748244778 cites W2003529673 @default.
• W2748244778 cites W2003562059 @default.
• W2748244778 cites W2005389394 @default.
• W2748244778 cites W2006104542 @default.
• W2748244778 cites W2006983377 @default.
• W2748244778 cites W2010922747 @default.
• W2748244778 cites W2015616022 @default.
• W2748244778 cites W2016045214 @default.
• W2748244778 cites W2018188180 @default.
• W2748244778 cites W2018241186 @default.
• W2748244778 cites W2019518887 @default.
• W2748244778 cites W2021231548 @default.
• W2748244778 cites W2022715098 @default.
• W2748244778 cites W2022865681 @default.
• W2748244778 cites W2022991465 @default.
• W2748244778 cites W2025396731 @default.
• W2748244778 cites W2027522332 @default.
• W2748244778 cites W2027847535 @default.
• W2748244778 cites W2028506868 @default.
• W2748244778 cites W2033036871 @default.
• W2748244778 cites W2034691005 @default.
• W2748244778 cites W2034749948 @default.
• W2748244778 cites W2035316083 @default.
• W2748244778 cites W2035386385 @default.
• W2748244778 cites W2035847639 @default.
• W2748244778 cites W2036144830 @default.
• W2748244778 cites W2039473712 @default.
• W2748244778 cites W2039675196 @default.
• W2748244778 cites W2040888996 @default.
• W2748244778 cites W2042529296 @default.
• W2748244778 cites W2045142779 @default.
• W2748244778 cites W2046981993 @default.
• W2748244778 cites W2047270074 @default.
• W2748244778 cites W2047764904 @default.
• W2748244778 cites W2048253455 @default.
• W2748244778 cites W2048529115 @default.
• W2748244778 cites W2049256895 @default.
• W2748244778 cites W2049764845 @default.
• W2748244778 cites W2049824915 @default.
• W2748244778 cites W2051536806 @default.
• W2748244778 cites W2057043051 @default.
• W2748244778 cites W2061135361 @default.
• W2748244778 cites W2061785856 @default.
• W2748244778 cites W2062459814 @default.
• W2748244778 cites W2064384444 @default.
• W2748244778 cites W2065447632 @default.
• W2748244778 cites W2065579911 @default.

• next