FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2748278329> ?p ?o ?g. }

• W2748278329 endingPage "4735" @default.
• W2748278329 startingPage "4729" @default.
• W2748278329 abstract "Lysosome associated membrane protein‑1 (LAMP1) is a heavily glycosylated lysosomal membrane protein, which is able to protect the lysosomal membrane from intracellular proteolysis. LAMP1 has been implicated in cancer development and progression. However, LAMP1 expression in breast cancer (BC) and its relationship with the clinical parameters of BC has not yet been fully investigated. In the present study, LAMP1 expression in BC was characterized by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) on 20 pairs of fresh‑frozen BC and corresponding non‑cancerous tissues. In addition, tissue microarray immunohistochemistry (TMA‑IHC) was conducted on 143 BC and matched non‑cancerous tissue samples. The results of RT‑qPCR and TMA‑IHC demonstrated that LAMP1 expression in BC tissues was significantly higher than in corresponding non‑cancerous tissues. Furthermore, LAMP1 protein expression levels were significantly associated with histological grade (P=0.047), estrogen receptor expression (P=0.003), progesterone receptor expression (P=0.002), molecular classification (P=0.022), lymph node metastasis (P=0.033) and tumor‑node‑metastasis (TNM) stage (P=0.012). Multivariate analysis using Cox regression models and Kaplan‑Meier survival curves demonstrated that LAMP1 expression (P=0.037), molecular classification (P=0.017) and TNM stage (P=0.003) were independent prognostic factors for overall survival. The above data suggested that LAMP1 expression is associated with malignant attributes of BC and may serve as a novel prognostic factor for patients with BC." @default.
• W2748278329 created "2017-08-31" @default.
• W2748278329 creator A5001890875 @default.
• W2748278329 creator A5020543727 @default.
• W2748278329 creator A5034923448 @default.
• W2748278329 creator A5054595087 @default.
• W2748278329 creator A5063722499 @default.
• W2748278329 creator A5066200744 @default.
• W2748278329 creator A5077734404 @default.
• W2748278329 creator A5080280424 @default.
• W2748278329 creator A5083351395 @default.
• W2748278329 date "2017-08-16" @default.
• W2748278329 modified "2023-10-06" @default.
• W2748278329 title "LAMP1 expression is associated with poor prognosis in breast cancer" @default.
• W2748278329 cites W133190493 @default.
• W2748278329 cites W1551743861 @default.
• W2748278329 cites W1561117001 @default.
• W2748278329 cites W1574603451 @default.
• W2748278329 cites W1826253058 @default.
• W2748278329 cites W1971049411 @default.
• W2748278329 cites W1983947354 @default.
• W2748278329 cites W1985213644 @default.
• W2748278329 cites W1994184760 @default.
• W2748278329 cites W2000607281 @default.
• W2748278329 cites W2009486394 @default.
• W2748278329 cites W2016133753 @default.
• W2748278329 cites W2027589717 @default.
• W2748278329 cites W2034279252 @default.
• W2748278329 cites W2038762894 @default.
• W2748278329 cites W2041973584 @default.
• W2748278329 cites W2042943663 @default.
• W2748278329 cites W2058682116 @default.
• W2748278329 cites W2062182686 @default.
• W2748278329 cites W2069274491 @default.
• W2748278329 cites W2080878773 @default.
• W2748278329 cites W2082433140 @default.
• W2748278329 cites W2092349886 @default.
• W2748278329 cites W2107277218 @default.
• W2748278329 cites W2109440441 @default.
• W2748278329 cites W2117692326 @default.
• W2748278329 cites W2132619562 @default.
• W2748278329 cites W2142280970 @default.
• W2748278329 cites W2169961966 @default.
• W2748278329 cites W2192080449 @default.
• W2748278329 cites W2219978888 @default.
• W2748278329 cites W23570259 @default.
• W2748278329 cites W2413635575 @default.
• W2748278329 cites W2597872842 @default.
• W2748278329 cites W294074848 @default.
• W2748278329 cites W48702940 @default.
• W2748278329 doi "https://doi.org/10.3892/ol.2017.6757" @default.
• W2748278329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5649640" @default.
• W2748278329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29085473" @default.
• W2748278329 hasPublicationYear "2017" @default.
• W2748278329 type Work @default.
• W2748278329 sameAs 2748278329 @default.
• W2748278329 citedByCount "25" @default.
• W2748278329 countsByYear W27482783292018 @default.
• W2748278329 countsByYear W27482783292019 @default.
• W2748278329 countsByYear W27482783292020 @default.
• W2748278329 countsByYear W27482783292021 @default.
• W2748278329 countsByYear W27482783292022 @default.
• W2748278329 countsByYear W27482783292023 @default.
• W2748278329 crossrefType "journal-article" @default.
• W2748278329 hasAuthorship W2748278329A5001890875 @default.
• W2748278329 hasAuthorship W2748278329A5020543727 @default.
• W2748278329 hasAuthorship W2748278329A5034923448 @default.
• W2748278329 hasAuthorship W2748278329A5054595087 @default.
• W2748278329 hasAuthorship W2748278329A5063722499 @default.
• W2748278329 hasAuthorship W2748278329A5066200744 @default.
• W2748278329 hasAuthorship W2748278329A5077734404 @default.
• W2748278329 hasAuthorship W2748278329A5080280424 @default.
• W2748278329 hasAuthorship W2748278329A5083351395 @default.
• W2748278329 hasBestOaLocation W27482783291 @default.
• W2748278329 hasConcept C102747710 @default.
• W2748278329 hasConcept C121608353 @default.
• W2748278329 hasConcept C126322002 @default.
• W2748278329 hasConcept C142724271 @default.
• W2748278329 hasConcept C170493617 @default.
• W2748278329 hasConcept C193270364 @default.
• W2748278329 hasConcept C204232928 @default.
• W2748278329 hasConcept C2777135640 @default.
• W2748278329 hasConcept C2779013556 @default.
• W2748278329 hasConcept C29537977 @default.
• W2748278329 hasConcept C502942594 @default.
• W2748278329 hasConcept C530470458 @default.
• W2748278329 hasConcept C67082663 @default.
• W2748278329 hasConcept C71924100 @default.
• W2748278329 hasConcept C86803240 @default.
• W2748278329 hasConceptScore W2748278329C102747710 @default.
• W2748278329 hasConceptScore W2748278329C121608353 @default.
• W2748278329 hasConceptScore W2748278329C126322002 @default.
• W2748278329 hasConceptScore W2748278329C142724271 @default.
• W2748278329 hasConceptScore W2748278329C170493617 @default.
• W2748278329 hasConceptScore W2748278329C193270364 @default.
• W2748278329 hasConceptScore W2748278329C204232928 @default.
• W2748278329 hasConceptScore W2748278329C2777135640 @default.
• W2748278329 hasConceptScore W2748278329C2779013556 @default.

• next