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- W2748344566 abstract "The development of controlled release drug delivery systems has increased, the release of drug from the dose is themost important step in controlled release dosage form design and to confirm the release is done properly, the kineticstudy must be take placed which described the overall release of drug from the dosage forms, because qualitative andquantitative changes in a formulation may alter drug release and in vivo performance, developing tools that facilitateproduct development by reducing the necessity of bio-studies is always desirable. In this regard, the use of in vitrodrug dissolution data to predict in vivo bio-performance can be considered as the rational development of controlledrelease formulations. The aim of this study is to evaluate drug release parameters as per various release kineticmodels. The tablets were characterized by physical and chemical parameters and results of assay% for the threebatches were found as 102.07(S.D = 1.11), 99.87(S.D = 1.45) and 100.52 (S.D = 1.72).within acceptable limits (90-110%). Different dissolution models were applied to drug release data in order to evaluate release mechanisms andkinetics. Criteria for selecting the most appropriate model was based on linearity (coefficient of correlation). Thedrug release data for drug fit well to the by zero order kinetics which give the highest r2 value (0.993), withanomalous release mechanism" @default.
- W2748344566 created "2017-08-31" @default.
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- W2748344566 date "2012-01-01" @default.
- W2748344566 modified "2023-09-24" @default.
- W2748344566 title "Evaluation of drug release kinetics for diclofenac sodium 100 mg origin brand matrix tablet" @default.
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