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- W2748448145 abstract "Objective To establish the rat brain glioma model and explore the proliferation of brain glioma and the expression of inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) gene influenced by the recombinant adeno-associated virus (rAAV-AsiNOS) in vivo.Methods C6 cells were injected into the right caudate nucleus areas of SD rats by stereotactic technology.After 7 days,rats were divided into 4 groups:control,rAAV-LacZ,rAAV-AsiNOS and blank.The neurological deficit score of all rats was separately acquired before the establishment of rat model,7 days after the establishment of rat model and 7 days after transfection.Seven days after transfection,the weight and volume of brain glioma were calculated by plain and enhanced MR scan.The expression of iNOS and VEGF was detected by using semi-quantified analysis of reverse transcriptase-polymerase chain reaction (RT-PCR).Resuits The neurological deficit score in rAAV-iNOS group was increased,but that in control and rAAVLacZ groups was reduced.MR images showed that brain tumors in control and rAAV-LacZ groups at 7th day after transfection were larger than before transfection,but the brain tumors in rAAV-iNOS group were obviously reduced.RT-PCR showed that mean expression levels of iNOS mRNA in control,rAAV-LacZ and rAAV-iNOS groups were separately 0.67 ±0.04,0.72 ±0.07 and 0.21 ±0.02,and mean expression levels of VEGF mRNA in control,rAAV-LacZ and rAAV-iNOS groups were separately 0.71 ± 0.08,0.76 ± 0.07 and 0.29 ± 0.02.The expression of iNOS and VEGF mRNA in rAAV-iNOS group was lower than that in control and rAAV-LacZ groups (P ＜0.05).Conclusion rAAV-iNOS can inhibit the expression of iNOS,regulate the synthesis of VEGF,reduce glioma angiogenesis and perform the mechanism of anti-glioma in vivo.Key words: Glioma; Inducible nitric oxide synthase; Vascular endothelial growth factor; Adeno-associated virus ; Angiogenesis" @default.
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- W2748448145 date "2013-12-08" @default.
- W2748448145 modified "2023-09-27" @default.
- W2748448145 title "Inhibition of rat brain glioma proliferation resulting from recombinant adeno-associated virus with nitricoxide synthaser of antisense gene" @default.
- W2748448145 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.12.041" @default.
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