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- W2748461144 abstract "Pancreatic ductal adenocarcinom (PDAC) is a highly mortal disease. We developed the tamoxifen-controllable LSL-RosaKE mouse model which enables pancreas-specific expression of KrasG12D from the murine Rosa26 locus to analyze the impact of KrasG12D on tumor maintenance. To monitor tumor cell proliferation in PDAC in vivo, the LSL-PCNAfLuc mouse model was used. Herein, firefly luciferase is expressed under control of the proliferating cell nuclear antigen (PCNA) promoter. Isolated PDAC cell lines were then used to develop a versatile high-throughput screening tool to identfy and validate potential drug candidates." @default.
- W2748461144 created "2017-08-31" @default.
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- W2748461144 date "2011-01-01" @default.
- W2748461144 modified "2023-09-23" @default.
- W2748461144 title "Downstream Signaling of Oncogenic Kras in Pancreatic Ductal Adenocarcinoma: In Vivo and Ex Vivo Imaging of Tumor Cell Proliferation as a Tool for the Identification of Therapeutic Targets" @default.
- W2748461144 hasPublicationYear "2011" @default.
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