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• W2748481024 abstract "Cutaneous leishmaniasis (CL) is the most common clinical form of American tegumentary leishmaniasis caused by Leishmania ( Viannia ) braziliensis . CL is associated with a strong Th1 immune response. This exacerbated inflammatory response is correlated with severity of disease and delays the healing time of the ulcer. The fourth-generation immucillin derivative (DI4G), a potent inhibitor of purine nucleoside phosphorylase, has been proposed as a promising agent in the treatment of diseases associated with T cell activation. Herein, we evaluated the in vitro immunomodulatory activity of DI4G in cells of patients presenting with CL. Peripheral blood mononuclear cells (PBMC) from CL patients were stimulated with soluble leishmania antigen (SLA), in the presence or absence of DI4G, and IFN- γ , TNF, CXCL9, and CXCL10 levels were determined by ELISA. Lymphocyte proliferation in the presence or absence of DI4G was also evaluated, using flow cytometry. DI4G was able to decrease (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>) IFN- γ production but did not change the TNF, CXCL9, and CXCL10 levels. DI4G decreased (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:math>) the lymphoproliferative response mediated by CD8 + T cells, but not that by CD4 + T cells. DI4G is able to attenuate the exaggerated immune response in CL, exhibiting immunomodulatory activity in IFN- γ production and in CD8 + T cell proliferation." @default.
• W2748481024 created "2017-08-31" @default.
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• W2748481024 date "2017-01-01" @default.
• W2748481024 modified "2023-10-14" @default.
• W2748481024 title "<i>In Vitro</i>Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis" @default.
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• W2748481024 doi "https://doi.org/10.1155/2017/3062892" @default.
• W2748481024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5591996" @default.
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