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• W2748534887 startingPage "40" @default.
• W2748534887 abstract "Glioblastoma multiforme (GBM) is a malignant tumor within the brain. Generally classified as primary and secondary with several different subtypes, ample molecular biomarkers have risen throughout the years which have garnered the attention of researchers. The advancements in genomics and proteomics have allowed researchers to gather prominent molecular biomarkers. All these biomarkers are gathered by means of biopsy or bodily fluid sample collection and are quantitatively analyzed by polymerase chain reaction coupled with other computational technologies. This review highlights the significance, regulation and prevalence of molecular biomarkers such as O6 -methylguanine-DNA methyltransferase, epidermal growth factor receptor vIII, isocitrate dehydrogenase mutation and several others which expressed differently in different types and molecular subtypes of GBM. The discoveries and roles of GBM-specific microRNAs including miR-21 and miR-10b as biomarkers with promising prognostic values were also delineated. The role and mechanism of biomarkers in GBM tumorigenesis are essential in the development of therapy for patients suffering from the disease itself. Thus, this review also discusses the mechanisms, effects and limitations of therapy such as temozolomide, viral gene transfer, biomarker-based vaccines or even engineered T cells for more specific responses. Biomarkers have displayed a high value and could eventually be utilized as drug targets. It is hoped that by combining different aspects of the disease which present with different biomarkers could lead to the development of a robust, effective and innovative take on GBM therapy." @default.
• W2748534887 created "2017-08-31" @default.
• W2748534887 creator A5045536753 @default.
• W2748534887 creator A5071337310 @default.
• W2748534887 creator A5081091932 @default.
• W2748534887 date "2017-08-25" @default.
• W2748534887 modified "2023-10-11" @default.
• W2748534887 title "Biomarkers and therapeutic advances in glioblastoma multiforme" @default.
• W2748534887 cites W1573845599 @default.
• W2748534887 cites W1881534971 @default.
• W2748534887 cites W1897662255 @default.
• W2748534887 cites W1916931627 @default.
• W2748534887 cites W1921809757 @default.
• W2748534887 cites W1941304965 @default.
• W2748534887 cites W1951559178 @default.
• W2748534887 cites W1963558982 @default.
• W2748534887 cites W1964422747 @default.
• W2748534887 cites W1969684282 @default.
• W2748534887 cites W197014098 @default.
• W2748534887 cites W1978221944 @default.
• W2748534887 cites W1978975870 @default.
• W2748534887 cites W1987480128 @default.
• W2748534887 cites W1988756388 @default.
• W2748534887 cites W1993605227 @default.
• W2748534887 cites W1995121204 @default.
• W2748534887 cites W1995963878 @default.
• W2748534887 cites W2001061723 @default.
• W2748534887 cites W2006241446 @default.
• W2748534887 cites W2010956784 @default.
• W2748534887 cites W2024473337 @default.
• W2748534887 cites W2028088729 @default.
• W2748534887 cites W2045866254 @default.
• W2748534887 cites W2046166482 @default.
• W2748534887 cites W2054727624 @default.
• W2748534887 cites W2055475004 @default.
• W2748534887 cites W2062753508 @default.
• W2748534887 cites W2063278152 @default.
• W2748534887 cites W2070897281 @default.
• W2748534887 cites W2072693177 @default.
• W2748534887 cites W2077393774 @default.
• W2748534887 cites W2077494872 @default.
• W2748534887 cites W2080452140 @default.
• W2748534887 cites W2083172345 @default.
• W2748534887 cites W2089559050 @default.
• W2748534887 cites W2097494801 @default.
• W2748534887 cites W2100809583 @default.
• W2748534887 cites W2103211592 @default.
• W2748534887 cites W2104607769 @default.
• W2748534887 cites W2104633297 @default.
• W2748534887 cites W2105100844 @default.
• W2748534887 cites W2110275053 @default.
• W2748534887 cites W2111963329 @default.
• W2748534887 cites W2113942802 @default.
• W2748534887 cites W2113992949 @default.
• W2748534887 cites W2114786150 @default.
• W2748534887 cites W2115020439 @default.
• W2748534887 cites W2125378172 @default.
• W2748534887 cites W2126817554 @default.
• W2748534887 cites W2128177155 @default.
• W2748534887 cites W2129825215 @default.
• W2748534887 cites W2131151598 @default.
• W2748534887 cites W2131403504 @default.
• W2748534887 cites W2139923932 @default.
• W2748534887 cites W2140301591 @default.
• W2748534887 cites W2143897427 @default.
• W2748534887 cites W2146519891 @default.
• W2748534887 cites W2146702849 @default.
• W2748534887 cites W2147482980 @default.
• W2748534887 cites W2150200928 @default.
• W2748534887 cites W2150309717 @default.
• W2748534887 cites W2151335185 @default.
• W2748534887 cites W2153152225 @default.
• W2748534887 cites W2156118453 @default.
• W2748534887 cites W2157183936 @default.
• W2748534887 cites W2158249814 @default.
• W2748534887 cites W2158681922 @default.
• W2748534887 cites W2159186332 @default.
• W2748534887 cites W2159355549 @default.
• W2748534887 cites W2161289668 @default.
• W2748534887 cites W2202848214 @default.
• W2748534887 cites W2226518372 @default.
• W2748534887 cites W2252317757 @default.
• W2748534887 cites W2262087088 @default.
• W2748534887 cites W2288159116 @default.
• W2748534887 cites W2314263138 @default.
• W2748534887 cites W2325549616 @default.
• W2748534887 cites W2328430405 @default.
• W2748534887 cites W2336798453 @default.
• W2748534887 cites W2386241382 @default.
• W2748534887 cites W2392045628 @default.
• W2748534887 cites W2416509920 @default.
• W2748534887 cites W2418524314 @default.
• W2748534887 cites W2463628623 @default.
• W2748534887 cites W2468950574 @default.
• W2748534887 cites W2508865759 @default.
• W2748534887 cites W2516978199 @default.
• W2748534887 cites W2553943144 @default.
• W2748534887 cites W2567424265 @default.

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