FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2748573668> ?p ?o ?g. }

• W2748573668 endingPage "e016528" @default.
• W2748573668 startingPage "e016528" @default.
• W2748573668 abstract "Vitamin D deficiency, elevated fibroblast growth factor 23 (FGF23) and elevated parathyroid hormone (PTH) have each been associated with increased mortality in people with chronic kidney disease (CKD). Previous studies have focused on the effects of FGF23 in relatively advanced CKD. This study aims to assess whether FGF23 is similarly a risk factor in people with early CKD, and how this risk compares to that associated with vitamin D deficiency or elevated PTH.Prospective cohort study.Thirty-two primary care practices.One thousand six hundred and sixty-four people who met Kidney Disease: Improving Global Outcomes (KDIGO) definitions for CKD stage 3 (two measurements of estimated glomerular filtration rate (eGFR) between 30 and 60 mL/min/1.73 m2 at least 90 days apart) prior to study recruitment.All-cause mortality over the period of study follow-up and progression of CKD defined as a 25% fall in eGFR and a drop in GFR category, or an increase in albuminuria category.Two hundred and eighty-nine participants died during the follow-up period. Vitamin D deficiency (HR 1.62, 95% CI 1.01 to 2.58) and elevated PTH (HR 1.42, 95% CI 1.09 to 1.84) were independently associated with all-cause mortality. FGF23 was associated with all-cause mortality in univariable but not multivariable analysis. Fully adjusted multivariable models of CKD progression showed no association with FGF23, vitamin D status or PTH.In this cohort of predominantly older people with CKD stage 3 and low risk of progression, vitamin D deficiency and elevated PTH were independent risk factors for all-cause mortality but elevated FGF23 was not. While FGF23 may have a role as a risk marker in high-risk populations managed in secondary care, our data suggest that it may not be as important in CKD stage 3, managed in primary care.National Institute for Health Research Clinical Research Portfolio Study Number 6632." @default.
• W2748573668 created "2017-08-31" @default.
• W2748573668 creator A5003065774 @default.
• W2748573668 creator A5005312226 @default.
• W2748573668 creator A5023778275 @default.
• W2748573668 creator A5027154690 @default.
• W2748573668 creator A5034192762 @default.
• W2748573668 date "2017-08-01" @default.
• W2748573668 modified "2023-10-16" @default.
• W2748573668 title "Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5-year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3" @default.
• W2748573668 cites W115572501 @default.
• W2748573668 cites W1803609188 @default.
• W2748573668 cites W1971484061 @default.
• W2748573668 cites W1973678023 @default.
• W2748573668 cites W1977645780 @default.
• W2748573668 cites W1992391557 @default.
• W2748573668 cites W1997015607 @default.
• W2748573668 cites W2008576263 @default.
• W2748573668 cites W2015668150 @default.
• W2748573668 cites W2035737520 @default.
• W2748573668 cites W2048729813 @default.
• W2748573668 cites W2051186854 @default.
• W2748573668 cites W2056875338 @default.
• W2748573668 cites W2074235486 @default.
• W2748573668 cites W2094551185 @default.
• W2748573668 cites W2099112155 @default.
• W2748573668 cites W2099604324 @default.
• W2748573668 cites W2100168006 @default.
• W2748573668 cites W2107420262 @default.
• W2748573668 cites W2110812622 @default.
• W2748573668 cites W2113457015 @default.
• W2748573668 cites W2125310135 @default.
• W2748573668 cites W2131843552 @default.
• W2748573668 cites W2136806600 @default.
• W2748573668 cites W2146159982 @default.
• W2748573668 cites W2149175313 @default.
• W2748573668 cites W2153059487 @default.
• W2748573668 cites W2155965977 @default.
• W2748573668 cites W2159532786 @default.
• W2748573668 cites W2164142357 @default.
• W2748573668 cites W2164952534 @default.
• W2748573668 cites W2167092665 @default.
• W2748573668 cites W2170815984 @default.
• W2748573668 cites W2288456186 @default.
• W2748573668 cites W2468655114 @default.
• W2748573668 cites W2511605914 @default.
• W2748573668 cites W2523134289 @default.
• W2748573668 cites W303691883 @default.
• W2748573668 doi "https://doi.org/10.1136/bmjopen-2017-016528" @default.
• W2748573668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5629682" @default.
• W2748573668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28838895" @default.
• W2748573668 hasPublicationYear "2017" @default.
• W2748573668 type Work @default.
• W2748573668 sameAs 2748573668 @default.
• W2748573668 citedByCount "23" @default.
• W2748573668 countsByYear W27485736682018 @default.
• W2748573668 countsByYear W27485736682019 @default.
• W2748573668 countsByYear W27485736682020 @default.
• W2748573668 countsByYear W27485736682021 @default.
• W2748573668 countsByYear W27485736682022 @default.
• W2748573668 countsByYear W27485736682023 @default.
• W2748573668 crossrefType "journal-article" @default.
• W2748573668 hasAuthorship W2748573668A5003065774 @default.
• W2748573668 hasAuthorship W2748573668A5005312226 @default.
• W2748573668 hasAuthorship W2748573668A5023778275 @default.
• W2748573668 hasAuthorship W2748573668A5027154690 @default.
• W2748573668 hasAuthorship W2748573668A5034192762 @default.
• W2748573668 hasBestOaLocation W27485736681 @default.
• W2748573668 hasConcept C114276007 @default.
• W2748573668 hasConcept C124490489 @default.
• W2748573668 hasConcept C126322002 @default.
• W2748573668 hasConcept C134018914 @default.
• W2748573668 hasConcept C159641895 @default.
• W2748573668 hasConcept C188816634 @default.
• W2748573668 hasConcept C201903717 @default.
• W2748573668 hasConcept C2776174234 @default.
• W2748573668 hasConcept C2778653478 @default.
• W2748573668 hasConcept C2779740938 @default.
• W2748573668 hasConcept C2781208988 @default.
• W2748573668 hasConcept C50440223 @default.
• W2748573668 hasConcept C519063684 @default.
• W2748573668 hasConcept C54847362 @default.
• W2748573668 hasConcept C71924100 @default.
• W2748573668 hasConcept C72563966 @default.
• W2748573668 hasConceptScore W2748573668C114276007 @default.
• W2748573668 hasConceptScore W2748573668C124490489 @default.
• W2748573668 hasConceptScore W2748573668C126322002 @default.
• W2748573668 hasConceptScore W2748573668C134018914 @default.
• W2748573668 hasConceptScore W2748573668C159641895 @default.
• W2748573668 hasConceptScore W2748573668C188816634 @default.
• W2748573668 hasConceptScore W2748573668C201903717 @default.
• W2748573668 hasConceptScore W2748573668C2776174234 @default.
• W2748573668 hasConceptScore W2748573668C2778653478 @default.
• W2748573668 hasConceptScore W2748573668C2779740938 @default.
• W2748573668 hasConceptScore W2748573668C2781208988 @default.
• W2748573668 hasConceptScore W2748573668C50440223 @default.
• W2748573668 hasConceptScore W2748573668C519063684 @default.
• W2748573668 hasConceptScore W2748573668C54847362 @default.

• next