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- W2748620570 abstract "In the past, the attention of physiologists and doctors has been mainly focused on the key role of acid in the pathogenesis of gastroesophageal reflux disease (GERD), but increasing evidence that 20-40% of reflux patients respond not at all or only partially to proton pump inhibitors (PPIs) has underlined the concept that factors other than acid are implicated in its development and the elicitation of symptoms. Among these, impaired mucosal integrity, particularly in most patients with non-erosive reflux disease, has recently been reincluded and the reinforcement of defensive mechanisms and/or its protection has been reappointed as a renewed therapeutic target for the management of GERD patients. In this review we will summarize the existing knowledge of the old and novel compounds able to produce this therapeutic effect, including sucralfate, alginate-based drugs, and a new medical device consisting of hyaluronic acid and chondroitin sulfate dispersed in a bioadhesive carrier, together with the potential indications for their use. It is to be stressed, however, that, although these compounds may represent a real alternative to PPI therapy in GERD, the combination of mucosal protection with acid suppression may help manage many cases with a partial or unsatisfactory response to PPIs alone." @default.
- W2748620570 created "2017-08-31" @default.
- W2748620570 creator A5001660061 @default.
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- W2748620570 date "2017-01-01" @default.
- W2748620570 modified "2023-10-16" @default.
- W2748620570 title "Drugs for improving esophageal mucosa defense: where are we now and where are we going?" @default.
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- W2748620570 cites W1973287240 @default.
- W2748620570 cites W1988373919 @default.
- W2748620570 cites W1992734182 @default.
- W2748620570 cites W1998949672 @default.
- W2748620570 cites W2001039702 @default.
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- W2748620570 cites W2010274194 @default.
- W2748620570 cites W2013275463 @default.
- W2748620570 cites W2023670929 @default.
- W2748620570 cites W2024517757 @default.
- W2748620570 cites W2027682237 @default.
- W2748620570 cites W2028236476 @default.
- W2748620570 cites W2032740971 @default.
- W2748620570 cites W2034803375 @default.
- W2748620570 cites W2036522080 @default.
- W2748620570 cites W2038864653 @default.
- W2748620570 cites W2039135176 @default.
- W2748620570 cites W2046585771 @default.
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- W2748620570 cites W2068504582 @default.
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- W2748620570 doi "https://doi.org/10.20524/aog.2017.0187" @default.
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- W2748620570 hasPublicationYear "2017" @default.
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