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- W2748629268 abstract "To determine age related changes in the ovaries and reproducibility of ultrasound measured parameters of ovarian ageing. Prospective follow-up study. Fifty-three women in reproductive ages with regular menstrual periods and proven fertility were included in the study. None of the participants had endocrine disorders, ovarian surgery or hormonal therapy during the last 12 months. All volunteers had menstrual day 3 ultrasound scanning by two experienced colleagues. First observer performed scanning immediately after first scan observer 2 performed scanning and after one hour of resting observer 1 repeated ultrasound examination. Correlation analysis was performed for age related changes in FSH, inhibin B, total antral follicle count (TAFC), total ovarian volume (TOV), stromal and ovarian Doppler flow indices of the first scanning of observer 1. Intraobserver and interobserver agreement was measured by correlation analysis and kappa calculation. Age was negatively correlated with TAFC (r=-0.61, p<0.001) but no correlation was found with TOV, inhibin B, FSH level, ovarian artery and ovarian stromal Doppler indices. Inhibin B was weakly correlated with TAFC (r=0.3, p=0.01) and FSH level was moderately negatively correlated with TAFC (r=-0.43, p=0.001). Intraobserver correlation was high for left ovarian volume (r=0.92, p<0.001), right ovarian volume (r=0.90, p=0.001), left ovarian antral follicle count (r=0.97, p<0.001) and right ovarian antral follicle count (r=0.96, p<0.001). Interobserver correlation was moderate for these measurements (respectively: r=0.73, p<0.001; r=0.48, p<0.001; r=0.71, p<0.001; r=0.69, p<0.001). When total follicle count and ovarian volume was calculated correlations improved. Intraobserver correlation for TAFC (r=0.98, p<0.001), for TOV (r=0.94, p<0.001) and interobserver correlation for TAFC (0.88, p<0.001) and for TOV (r=0.79, p<0.001) showed strong positive correlation. Interobserver agreement for TAFC was moderate (kappa=0.49). No intraobserver or interobserver correlation was found in Doppler flow indices. Age was only correlated with total antral follicle count which was the most reproducible ultrasound measurement." @default.
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- W2748629268 date "2006-09-01" @default.
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- W2748629268 title "O-123" @default.
- W2748629268 doi "https://doi.org/10.1016/j.fertnstert.2006.07.143" @default.
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