Matches in SemOpenAlex for { <https://semopenalex.org/work/W2748853669> ?p ?o ?g. }
- W2748853669 abstract "Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long been debated. Here, using mice expressing one of two different T cell receptor β chains and various MHC alleles, we show that positive selection-induced MHC bias of T cell receptors is affected both by the germline encoded elements of the T cell receptor α and β chain and, surprisingly, dramatically affected by the non germ line encoded portions of CDR3 of the T cell receptor α chain. Thus, in addition to determining specificity for antigen, the non germline encoded elements of T cell receptors may help the proteins cope with the extremely polymorphic nature of major histocompatibility complex products within the species." @default.
- W2748853669 created "2017-08-31" @default.
- W2748853669 creator A5019794250 @default.
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- W2748853669 creator A5079981659 @default.
- W2748853669 creator A5082152121 @default.
- W2748853669 creator A5085684637 @default.
- W2748853669 date "2017-11-17" @default.
- W2748853669 modified "2023-10-16" @default.
- W2748853669 title "The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor" @default.
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