Matches in SemOpenAlex for { <https://semopenalex.org/work/W2748923304> ?p ?o ?g. }
- W2748923304 endingPage "115" @default.
- W2748923304 startingPage "106" @default.
- W2748923304 abstract "Rheumatoid arthritis (RA) is a chronic autoimmune mediated joint disease with severe complications affecting 1% of the population worldwide. Although the exact mechanism underlying the aggravation of RA remains unknown, its occurrence can lead to joint degradation and functional disability. Recent evidences have shown that the aberrant expression of microRNAs (miRNAs) play a prominent role in the furtherance of RA. Over the last decade, various intensive studies have validated different microRNAs to be good candidates for diagnostic purposes and for monitoring the disease progression in various inflammatory diseases. A deeper understanding of the molecular mechanism through which miRNAs amplify the production of inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-17), pro-inflammatory mediators, growth factors and MMPs will act as potential therapeutic targets. More importantly, several studies have briefly reported the crucial role of TLR dependent MAPK signaling pathway, which mediates the pathological features of RA. In this review, we summarize the recent findings and provide a detailed report of the molecular mechanism of microRNA along with the role of TLR/MAPK signaling pathway in RA. However, the major aim of this review is to correlate the aberrantly expressed microRNAs in TLR/MAPK pathway with various well reported bioactive compounds that can modulate these signaling pathways in rheumatoid arthritis. Targeting miRNA expression using specific bioactive compounds might be a potent and an effective target in RA treatment by suppressing the TLR/MAPK pathway." @default.
- W2748923304 created "2017-08-31" @default.
- W2748923304 creator A5011206344 @default.
- W2748923304 creator A5043136416 @default.
- W2748923304 date "2017-10-01" @default.
- W2748923304 modified "2023-10-05" @default.
- W2748923304 title "MicroRNAs and bioactive compounds on TLR/MAPK signaling in rheumatoid arthritis" @default.
- W2748923304 cites W1224580755 @default.
- W2748923304 cites W1248878113 @default.
- W2748923304 cites W144423133 @default.
- W2748923304 cites W1483162601 @default.
- W2748923304 cites W1538469697 @default.
- W2748923304 cites W1600472471 @default.
- W2748923304 cites W1602757363 @default.
- W2748923304 cites W1604827622 @default.
- W2748923304 cites W1799806109 @default.
- W2748923304 cites W1969072247 @default.
- W2748923304 cites W1971521446 @default.
- W2748923304 cites W1972703426 @default.
- W2748923304 cites W1979206745 @default.
- W2748923304 cites W1980269624 @default.
- W2748923304 cites W1983830700 @default.
- W2748923304 cites W1985492450 @default.
- W2748923304 cites W1987617704 @default.
- W2748923304 cites W1989015932 @default.
- W2748923304 cites W1992032030 @default.
- W2748923304 cites W1992868109 @default.
- W2748923304 cites W1995744610 @default.
- W2748923304 cites W1996575556 @default.
- W2748923304 cites W1998450288 @default.
- W2748923304 cites W1999958013 @default.
- W2748923304 cites W2000468514 @default.
- W2748923304 cites W2001428704 @default.
- W2748923304 cites W2003086027 @default.
- W2748923304 cites W2004773897 @default.
- W2748923304 cites W2017264140 @default.
- W2748923304 cites W2017762858 @default.
- W2748923304 cites W2018058756 @default.
- W2748923304 cites W2020599612 @default.
- W2748923304 cites W2023910122 @default.
- W2748923304 cites W2024206172 @default.
- W2748923304 cites W2024716296 @default.
- W2748923304 cites W2026067244 @default.
- W2748923304 cites W2027225108 @default.
- W2748923304 cites W2027424386 @default.
- W2748923304 cites W2031503714 @default.
- W2748923304 cites W2032696674 @default.
- W2748923304 cites W2033056618 @default.
- W2748923304 cites W2033459613 @default.
- W2748923304 cites W2033581905 @default.
- W2748923304 cites W2038328354 @default.
- W2748923304 cites W2040426028 @default.
- W2748923304 cites W2040639783 @default.
- W2748923304 cites W2044331454 @default.
- W2748923304 cites W2045402423 @default.
- W2748923304 cites W2047217935 @default.
- W2748923304 cites W2049907045 @default.
- W2748923304 cites W2050066579 @default.
- W2748923304 cites W2050359926 @default.
- W2748923304 cites W2052204806 @default.
- W2748923304 cites W2054538838 @default.
- W2748923304 cites W2056603566 @default.
- W2748923304 cites W2057419005 @default.
- W2748923304 cites W2057911711 @default.
- W2748923304 cites W2060630008 @default.
- W2748923304 cites W2061792288 @default.
- W2748923304 cites W2062903634 @default.
- W2748923304 cites W2067179334 @default.
- W2748923304 cites W2067654102 @default.
- W2748923304 cites W2070044720 @default.
- W2748923304 cites W2071181000 @default.
- W2748923304 cites W2073745335 @default.
- W2748923304 cites W2074072621 @default.
- W2748923304 cites W2075810631 @default.
- W2748923304 cites W2075860675 @default.
- W2748923304 cites W2083767818 @default.
- W2748923304 cites W2087032228 @default.
- W2748923304 cites W2088853673 @default.
- W2748923304 cites W2091061305 @default.
- W2748923304 cites W2091262754 @default.
- W2748923304 cites W2099802544 @default.
- W2748923304 cites W2101866294 @default.
- W2748923304 cites W2118343231 @default.
- W2748923304 cites W2118519694 @default.
- W2748923304 cites W2119015197 @default.
- W2748923304 cites W2119474463 @default.
- W2748923304 cites W2124354788 @default.
- W2748923304 cites W2125792512 @default.
- W2748923304 cites W2126275198 @default.
- W2748923304 cites W2127551467 @default.
- W2748923304 cites W2130894316 @default.
- W2748923304 cites W2133500662 @default.
- W2748923304 cites W2135768118 @default.
- W2748923304 cites W2138090246 @default.
- W2748923304 cites W2138664009 @default.
- W2748923304 cites W2138972371 @default.
- W2748923304 cites W2139791626 @default.
- W2748923304 cites W2140861987 @default.