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- W2748967805 abstract "Background: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepatitis. Objectives: The objective of this study was to show the efficacy of topical mycophenolate mofetil in the treatment of vitiligo. Methods: Thirty patients with limited vitiligo were enrolled in this study. The patients applied a topical preparation of mycophenolate mofetil 15% twice daily for three months and at the end of every month, repigmentation was assessed using the Vitiligo Area Scoring Index (VASI). Results: At the end of the third month, 36.6 % (n=11) of the patients showed about 25% repigmentation of the lesions. No side effects were observed throughout the study. Conclusion: This study showed that topical mycophenolate mofetil can be somewhat effective in the treatment of vitiligo; however, it seems to be inferior to potent topical steroids in inducing repigmentation." @default.
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- W2748967805 date "2017-04-30" @default.
- W2748967805 modified "2023-10-17" @default.
- W2748967805 title "opical mycophenolate mofetil in the treatment of vitiligo: a pilot study" @default.
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- W2748967805 doi "https://doi.org/10.5826/dpc.0702a06" @default.
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