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- W2749007890 abstract "Streptococcus pyogenes is a β-hemolytic organism responsible for a wide variety of human diseases that commonly occur as self-limiting purulent diseases of the pharynx and skin. Although the occurrence of invasive infections by S. pyogenes is rare, mortality rates remain high even with progressive medical therapy. As a prerequisite for causing the severe invasive disease, S. pyogenes must invade underlying sterile tissues by translocating across the epithelial barrier. In this study, streptolysin S and SpeB were identified as the novel factors that facilitate bacterial translocation via degradation of intercellular junctions. Furthermore, we found that S. pyogenes exploits host plasminogen for acceleration of bacterial invasion into deeper tissues via tricellular tight junctions. Here, I would like to show our study on bacterial translocation across the epithelial barrier through paracellular route." @default.
- W2749007890 created "2017-08-31" @default.
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- W2749007890 date "2017-01-01" @default.
- W2749007890 modified "2023-10-16" @default.
- W2749007890 title "<i>Streptococcus pyogenes</i> translocates across an epithelial barrier" @default.
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- W2749007890 doi "https://doi.org/10.3412/jsb.72.213" @default.
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