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• W2749063756 abstract "To determine if the embryo regulates uterine steroidogenesis during decidualization. Recurrent pregnancy loss is a common barrier to successful pregnancy. A clearer understanding of the molecular dialog that exists between the mother and developing embryo is essential if we hope to identify therapeutic remedies to reduce pregnancy loss. Uterine decidualization is a carefully orchestrated event critical for providing a suitable environment for the implantation and support of a developing embryo. There is some evidence that decidualized uterine stromal tissue produces progesterone during pregnancy; however, the nature by which steroid synthesis is regulated in the uterine deciduum is poorly understood. Using microarray analysis we tested the hypothesis that decidual gene expression is activated for synthesis of progesterone when compared to artificially an induced deciuoma. Experimental Study Female mice (ICR, 10-12 wks) were bred with intact or vasectomized males to initiate pregnancy (P) or pseudopregnancy (PP), respectively. On day 7.5 of PP, sesame oil was infused into one uterine horn to initiate decidualization in place of the embryo, while the unstimulated horn was used as the control. RNA was isolated from uterine tissue (decidualized and non-decidualized) on day 7.5 of P or PP, and a genome-wide expression profile was established using Affymetrix Microarray technology (Mouse 430 2.0 chip) to compare oil- versus embryo-induced decidualization. All experiments were performed in triplicate. Pathway analysis was performed using the Gene Sifter Microarray analysis system. RT-PCR was then used to validate array data in which steroidogenic genes were of particular interest. In contrast to the non-decidualized uterus, oil-induced decidualization markedly increased expression of several genes that encode proteins at multiple levels of the steroidogenic pathway. Interestingly, several of these steroidogenic genes were differentially regulated in the decidulized stomal compartment in the presence of an embryo. For example, aldo-keto reductase (AKR) 1c18, steroidogenic acute regulatory (StAR) protein, and diazepam binding inhibitor DBI were expressed at higher levels in decidual tissue during P compared to PP, whereas hydroxysteroid dehydrogenase (HSD) 3b6 and very low density lipoprotein receptor (VLDLr) were down-regulated by the presence of the embryo. The decidualizing uterine stromal compartment, in addition to the ovarian corpus luteum and placenta, is a site of steroid synthesis during early gestation, and the embryo provides signaling cues to tightly regulate steroid biosynthesis at the maternal:embryo interface. Additional studies are necessary to demonstrate the functional significance of uterine steroid biosynthesis during gestation, and to identify the embryonic signaling factors that regulate genes involved in uterine steroidogenesis." @default.
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• W2749063756 date "2006-09-01" @default.
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• W2749063756 title "P-554" @default.
• W2749063756 doi "https://doi.org/10.1016/j.fertnstert.2006.07.923" @default.
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