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- W2749202673 abstract "Apatinib in the treatment of advanced lung adenocarcinoma with KRAS mutation Da-xiong Zeng,* Chang-guo Wang,* Jian-an Huang, Jun-hong Jiang Department of Respiratory and Critical Care, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China *These authors contributed equally to this work Abstract: Activating KRAS mutations in lung adenocarcinoma are characterized with treatment resistance and poor prognosis. As a small molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase, apatinib has been proven successful in advanced gastric cancer and breast cancer. In this study, we show the result of apatinib as salvage treatment in lung adenocarcinoma patients with KRAS mutation. Four advanced lung adenocarcinoma patients with KRAS mutation were orally administered apatinib (250 mg/d) after second-line treatment. One patient showed progressive disease, while 3 patients showed stable disease response to apatinib, with a median progression-free survival (PFS) of 3.8 months (1.5–5.5 months). The main toxicities were hoarseness and hemoptysis, which were manageable. Therefore, apatinib might be an optional choice for advanced lung adenocarcinoma patients with KRAS mutation in post second-line treatment. Keywords: lung cancer, apatinib, VEGFR-2, KRAS mutation" @default.
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- W2749202673 date "2017-08-01" @default.
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- W2749202673 title "Apatinib in the treatment of advanced lung adenocarcinoma with KRAS mutation" @default.
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- W2749202673 doi "https://doi.org/10.2147/ott.s139520" @default.
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