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- W2749302750 endingPage "5634" @default.
- W2749302750 startingPage "5634" @default.
- W2749302750 abstract "To critically review the literature addressing the definition, epidemiology, aetiology and pathophysiology of acute colonic pseudo-obstruction (ACPO).A systematic search was performed to identify articles investigating the aetiology and pathophysiology of ACPO. A narrative synthesis of the evidence was undertaken.No consistent approach to the definition or reporting of ACPO has been developed, which has led to overlapping investigation with other conditions. A vast array of risk factors has been identified, supporting a multifactorial aetiology. The pathophysiological mechanisms remain unclear, but are likely related to altered autonomic regulation of colonic motility, in the setting of other predisposing factors.Future research should aim to establish a clear and consistent definition of ACPO, and elucidate the pathophysiological mechanisms leading to altered colonic function. An improved understanding of the aetiology of ACPO may facilitate the development of targeted strategies for its prevention and treatment." @default.
- W2749302750 created "2017-08-31" @default.
- W2749302750 creator A5012266085 @default.
- W2749302750 creator A5054870110 @default.
- W2749302750 creator A5066167977 @default.
- W2749302750 date "2017-01-01" @default.
- W2749302750 modified "2023-09-30" @default.
- W2749302750 title "Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms" @default.
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