FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2749331808> ?p ?o ?g. }

• W2749331808 endingPage "21" @default.
• W2749331808 startingPage "14" @default.
• W2749331808 abstract "Metformin has received increasing attention for its potential anticancer activity against certain human leukemia cells, but its effects on human megakaryoblastic cells are unclear. This study aimed to investigate the effects of metformin on proliferation and apoptosis of human megakaryoblastic cells (Dami and MEG-01) and the underlying molecular mechanisms. CCK8 assay was employed to measure cell proliferation. Flow cytometry was adopted to detect cell apoptosis. Western blot was further employed to measure apoptosis-related proteins. In Dami and MEG-01 cells, metformin significantly inhibited proliferation and promoted apoptosis in a dose- and time-dependent manner, and metformin (4 mM) was selected for subsequent experiments. Metformin inhibited ERK1/2, JNK, and PI3K/Akt, but activated p38 pathway in these two cells. Moreover, inhibition of ERK1/2, JNK or PI3K/Akt pathway alone induced cell apoptosis compared to the control group. The combination of specific inhibitors of ERK1/2, JNK or PI3K/Akt pathway and metformin further promoted cell apoptosis and the up-regulation of p21, Bax, Bad, cleaved caspase-3 and -9 as well as the down-regulation of Bcl-2 mediated by metformin alone, but inhibition of p38 pathway exhibited the opposite results. These findings support the possibility of metformin treatment as a new therapeutic strategy against acute megakaryoblastic leukemia (AMKL)." @default.
• W2749331808 created "2017-08-31" @default.
• W2749331808 creator A5007145244 @default.
• W2749331808 creator A5026041527 @default.
• W2749331808 creator A5027459729 @default.
• W2749331808 creator A5033684035 @default.
• W2749331808 creator A5046938200 @default.
• W2749331808 creator A5086896775 @default.
• W2749331808 date "2017-09-01" @default.
• W2749331808 modified "2023-10-16" @default.
• W2749331808 title "Effects of metformin on proliferation and apoptosis of human megakaryoblastic Dami and MEG-01 cells" @default.
• W2749331808 cites W1161220759 @default.
• W2749331808 cites W1498846183 @default.
• W2749331808 cites W1613319667 @default.
• W2749331808 cites W1945687110 @default.
• W2749331808 cites W1969542174 @default.
• W2749331808 cites W1974300980 @default.
• W2749331808 cites W1976577016 @default.
• W2749331808 cites W1980078856 @default.
• W2749331808 cites W1981802649 @default.
• W2749331808 cites W1986740965 @default.
• W2749331808 cites W1999485687 @default.
• W2749331808 cites W2015511757 @default.
• W2749331808 cites W2020184457 @default.
• W2749331808 cites W2020226666 @default.
• W2749331808 cites W2021074776 @default.
• W2749331808 cites W2024105041 @default.
• W2749331808 cites W2036864615 @default.
• W2749331808 cites W2038264502 @default.
• W2749331808 cites W2039212784 @default.
• W2749331808 cites W2043310375 @default.
• W2749331808 cites W2050673593 @default.
• W2749331808 cites W2059764223 @default.
• W2749331808 cites W2076104235 @default.
• W2749331808 cites W2082970014 @default.
• W2749331808 cites W2083911670 @default.
• W2749331808 cites W2124529427 @default.
• W2749331808 cites W2129335046 @default.
• W2749331808 cites W2134295452 @default.
• W2749331808 cites W2138226825 @default.
• W2749331808 cites W2145540652 @default.
• W2749331808 cites W2146788325 @default.
• W2749331808 cites W2153607816 @default.
• W2749331808 cites W2158943292 @default.
• W2749331808 cites W2161972779 @default.
• W2749331808 cites W2164882663 @default.
• W2749331808 cites W2166583179 @default.
• W2749331808 cites W2399576841 @default.
• W2749331808 cites W2404349210 @default.
• W2749331808 cites W4231346141 @default.
• W2749331808 doi "https://doi.org/10.1016/j.jphs.2017.08.003" @default.
• W2749331808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28927780" @default.
• W2749331808 hasPublicationYear "2017" @default.
• W2749331808 type Work @default.
• W2749331808 sameAs 2749331808 @default.
• W2749331808 citedByCount "16" @default.
• W2749331808 countsByYear W27493318082017 @default.
• W2749331808 countsByYear W27493318082018 @default.
• W2749331808 countsByYear W27493318082019 @default.
• W2749331808 countsByYear W27493318082020 @default.
• W2749331808 countsByYear W27493318082021 @default.
• W2749331808 countsByYear W27493318082022 @default.
• W2749331808 countsByYear W27493318082023 @default.
• W2749331808 crossrefType "journal-article" @default.
• W2749331808 hasAuthorship W2749331808A5007145244 @default.
• W2749331808 hasAuthorship W2749331808A5026041527 @default.
• W2749331808 hasAuthorship W2749331808A5027459729 @default.
• W2749331808 hasAuthorship W2749331808A5033684035 @default.
• W2749331808 hasAuthorship W2749331808A5046938200 @default.
• W2749331808 hasAuthorship W2749331808A5086896775 @default.
• W2749331808 hasBestOaLocation W27493318081 @default.
• W2749331808 hasConcept C104317684 @default.
• W2749331808 hasConcept C134018914 @default.
• W2749331808 hasConcept C185592680 @default.
• W2749331808 hasConcept C190283241 @default.
• W2749331808 hasConcept C203014093 @default.
• W2749331808 hasConcept C2776415932 @default.
• W2749331808 hasConcept C2778378607 @default.
• W2749331808 hasConcept C2778461978 @default.
• W2749331808 hasConcept C2780323712 @default.
• W2749331808 hasConcept C502942594 @default.
• W2749331808 hasConcept C51551487 @default.
• W2749331808 hasConcept C553184892 @default.
• W2749331808 hasConcept C55493867 @default.
• W2749331808 hasConcept C555293320 @default.
• W2749331808 hasConcept C57074206 @default.
• W2749331808 hasConcept C62112901 @default.
• W2749331808 hasConcept C62478195 @default.
• W2749331808 hasConcept C75217442 @default.
• W2749331808 hasConcept C86554907 @default.
• W2749331808 hasConcept C86803240 @default.
• W2749331808 hasConcept C95444343 @default.
• W2749331808 hasConceptScore W2749331808C104317684 @default.
• W2749331808 hasConceptScore W2749331808C134018914 @default.
• W2749331808 hasConceptScore W2749331808C185592680 @default.
• W2749331808 hasConceptScore W2749331808C190283241 @default.
• W2749331808 hasConceptScore W2749331808C203014093 @default.
• W2749331808 hasConceptScore W2749331808C2776415932 @default.

• next