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• W2749472324 endingPage "2170" @default.
• W2749472324 startingPage "2161" @default.
• W2749472324 abstract "Despite having physiological functions completely different from superoxide dismutase 1 (SOD1), profilin 1 (PFN1) also carries mutations causing amyotrophic lateral sclerosis (ALS) with a striking similarity to that triggered by SOD1 mutants. Very recently, the C71G-PFN1 has been demonstrated to cause ALS by a gain of toxicity and the acceleration of motor neuron degeneration preceded the accumulation of its aggregates. Here by atomic-resolution NMR determination of conformations and dynamics of WT-PFN1 and C71G-PFN1 in aqueous buffers and in membrane mimetics DMPC/DHPC bicelle and DPC micelle, we deciphered that: 1) the thermodynamic destabilization by C71G transforms PFN1 into coexistence with the unfolded state, which is lacking of any stable tertiary/secondary structures as well as restricted ps-ns backbone motions, thus fundamentally indistinguishable from ALS-causing SOD1 mutants. 2) Most strikingly, while WT-PFN1 only weakly interacts with DMPC/DHPC bicelle without altering the native structure, C71G-PFN1 acquires abnormal capacity in strongly interacting with DMPC/DHPC bicelle and DPC micelle, energetically driven by transforming the highly disordered unfolded state into a non-native helical structure, similar to what has been previously observed on ALS-causing SOD1 mutants. Our results imply that one potential mechanism for C71G-PFN1 to initiate ALS might be the abnormal interaction with membranes as recently established for SOD1 mutants." @default.
• W2749472324 created "2017-08-31" @default.
• W2749472324 creator A5038512105 @default.
• W2749472324 creator A5046217738 @default.
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• W2749472324 date "2017-11-01" @default.
• W2749472324 modified "2023-09-29" @default.
• W2749472324 title "ALS-causing profilin-1-mutant forms a non-native helical structure in membrane environments" @default.
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• W2749472324 doi "https://doi.org/10.1016/j.bbamem.2017.08.013" @default.
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