Matches in SemOpenAlex for { <https://semopenalex.org/work/W2749602320> ?p ?o ?g. }
- W2749602320 endingPage "474" @default.
- W2749602320 startingPage "460" @default.
- W2749602320 abstract "Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-associated declines in stem cell function are characterized by metabolic and epigenetic changes. Understanding the mechanisms underlying these changes will likely reveal novel therapeutic targets for ameliorating age-associated phenotypes and for prolonging human healthspan. Recent studies have shown that metabolism plays an important role in regulating epigenetic modifications and that this regulation dramatically affects the aging process. This review focuses on current knowledge regarding the mechanisms of stem cell aging, and the links between cellular metabolism and epigenetic regulation. In addition, we discuss how these interactions sense and respond to environmental stress in order to maintain stem cell homeostasis, and how environmental stimuli regulate stem cell function. Additionally, we highlight recent advances in the development of therapeutic strategies to rejuvenate dysfunctional aged stem cells." @default.
- W2749602320 created "2017-08-31" @default.
- W2749602320 creator A5027353592 @default.
- W2749602320 creator A5050690657 @default.
- W2749602320 creator A5053323823 @default.
- W2749602320 creator A5071577840 @default.
- W2749602320 date "2017-09-01" @default.
- W2749602320 modified "2023-10-15" @default.
- W2749602320 title "Regulation of Stem Cell Aging by Metabolism and Epigenetics" @default.
- W2749602320 cites W1493263872 @default.
- W2749602320 cites W1500247249 @default.
- W2749602320 cites W1508556872 @default.
- W2749602320 cites W1817033456 @default.
- W2749602320 cites W1834348670 @default.
- W2749602320 cites W1847809821 @default.
- W2749602320 cites W1869763094 @default.
- W2749602320 cites W1964204876 @default.
- W2749602320 cites W1965006127 @default.
- W2749602320 cites W1965306647 @default.
- W2749602320 cites W1966132436 @default.
- W2749602320 cites W1967412255 @default.
- W2749602320 cites W1969905245 @default.
- W2749602320 cites W1969984078 @default.
- W2749602320 cites W1970338621 @default.
- W2749602320 cites W1972726904 @default.
- W2749602320 cites W1974396693 @default.
- W2749602320 cites W1974470246 @default.
- W2749602320 cites W1978269248 @default.
- W2749602320 cites W1978927200 @default.
- W2749602320 cites W1981463076 @default.
- W2749602320 cites W1984173288 @default.
- W2749602320 cites W1984358237 @default.
- W2749602320 cites W1989674299 @default.
- W2749602320 cites W1990928498 @default.
- W2749602320 cites W1993355054 @default.
- W2749602320 cites W1994143270 @default.
- W2749602320 cites W1994471840 @default.
- W2749602320 cites W1995706959 @default.
- W2749602320 cites W1996395636 @default.
- W2749602320 cites W1999218428 @default.
- W2749602320 cites W1999298001 @default.
- W2749602320 cites W1999967032 @default.
- W2749602320 cites W2006588853 @default.
- W2749602320 cites W2010583480 @default.
- W2749602320 cites W2013139068 @default.
- W2749602320 cites W2013742279 @default.
- W2749602320 cites W2014892893 @default.
- W2749602320 cites W2017303317 @default.
- W2749602320 cites W2020156629 @default.
- W2749602320 cites W2022487205 @default.
- W2749602320 cites W2024123645 @default.
- W2749602320 cites W2028786309 @default.
- W2749602320 cites W2029054948 @default.
- W2749602320 cites W2030466057 @default.
- W2749602320 cites W2030484015 @default.
- W2749602320 cites W2030509917 @default.
- W2749602320 cites W2030865407 @default.
- W2749602320 cites W2031126348 @default.
- W2749602320 cites W2032022203 @default.
- W2749602320 cites W2032867856 @default.
- W2749602320 cites W2034667463 @default.
- W2749602320 cites W2035564874 @default.
- W2749602320 cites W2036055444 @default.
- W2749602320 cites W2038069027 @default.
- W2749602320 cites W2038897056 @default.
- W2749602320 cites W2038907283 @default.
- W2749602320 cites W2041336414 @default.
- W2749602320 cites W2044897807 @default.
- W2749602320 cites W2045856411 @default.
- W2749602320 cites W2048376025 @default.
- W2749602320 cites W2048637593 @default.
- W2749602320 cites W2048967691 @default.
- W2749602320 cites W2050166933 @default.
- W2749602320 cites W2050838528 @default.
- W2749602320 cites W2053493267 @default.
- W2749602320 cites W2055807959 @default.
- W2749602320 cites W2056077438 @default.
- W2749602320 cites W2058484936 @default.
- W2749602320 cites W2063062036 @default.
- W2749602320 cites W2063891109 @default.
- W2749602320 cites W2065564965 @default.
- W2749602320 cites W2066442023 @default.
- W2749602320 cites W2066843562 @default.
- W2749602320 cites W2066899457 @default.
- W2749602320 cites W2069519394 @default.
- W2749602320 cites W2072528578 @default.
- W2749602320 cites W2072810104 @default.
- W2749602320 cites W2073610802 @default.
- W2749602320 cites W2074065976 @default.
- W2749602320 cites W2074782816 @default.
- W2749602320 cites W2078291208 @default.
- W2749602320 cites W2078575160 @default.
- W2749602320 cites W2079983476 @default.
- W2749602320 cites W2080094749 @default.
- W2749602320 cites W2080472500 @default.
- W2749602320 cites W2082121028 @default.
- W2749602320 cites W2082182268 @default.
- W2749602320 cites W2082603625 @default.