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• W2749633151 endingPage "31496" @default.
• W2749633151 startingPage "31488" @default.
• W2749633151 abstract "Cochlear Implants (CIs) suffer from limited tonal resolution due, in large part, to spatial separation between stimulating electrode arrays and primary neural receptors. In this work, a combination of physical and chemical micropatterns, formed on acrylate polymers, are used to direct the growth of primary spiral ganglion neurons (SGNs), the inner ear neurons. Utilizing the inherent temporal and spatial control of photopolymerization, physical microgrooves are fabricated using a photomask in a single step process. Biochemical patterns are generated by adsorbing laminin, a cell adhesion protein, to acrylate polymer surfaces followed by irradiation through a photomask with UV light to deactivate protein in exposed areas and generate parallel biochemical patterns. Laminin deactivation was shown increase as a function of UV light exposure while remaining adsorbed to the polymer surface. SGN neurites show alignment to both biochemical and physical patterns when evaluated individually. Competing biochemical and physical patterns were also examined. The relative guiding strength of physical cues was varied by independently changing both the amplitude and the band spacing of the microgrooves, with higher amplitudes and shorter band spacing providing cues that more effective guide neurite growth. SGN neurites aligned to laminin patterns with lower physical pattern amplitude and thus weaker physical cues. Alignment of SGNs shifted toward the physical pattern with higher amplitude and lower periodicity patterns which represent stronger cues. These results demonstrate the ability of photopolymerized microfeatures to modulate alignment of inner ear neurites even in the presence of conflicting physical and biochemical cues laying the groundwork for next generation cochlear implants and neural prosthetic devices." @default.
• W2749633151 created "2017-08-31" @default.
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• W2749633151 date "2017-09-05" @default.
• W2749633151 modified "2023-09-24" @default.
• W2749633151 title "Tuning Surface and Topographical Features to Investigate Competitive Guidance of Spiral Ganglion Neurons" @default.
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• W2749633151 doi "https://doi.org/10.1021/acsami.7b09258" @default.
• W2749633151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6341486" @default.
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