FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2749677185> ?p ?o ?g. }

• W2749677185 endingPage "1487" @default.
• W2749677185 startingPage "1476" @default.
• W2749677185 abstract "In a randomized, double-blind, placebo controlled trial, we investigated the postoperative analgesic effect of a single intra-articular injection of 40 mg methylprednisolone acetate (MP) administered 1 week before total knee arthroplasty (TKA). Forty-eight patients with high pain osteoarthritis (≥5 on a numeric rating scale during walk) and sensitization (pressure pain threshold <250 kPa), aged 50 to 80 years and scheduled for primary unilateral TKA under spinal anaesthesia were included. The primary outcome was the proportion of patients with moderate/severe pain during a 5-m walk test 24 hours postoperatively. Secondary outcomes included pain at 48 hours, during the first 14 days, sensitization (quantitative sensory testing with pressure pain threshold and wind-up from temporal summation), and inflammatory changes (systemic C-reactive protein, intra-articular interleukin [IL]-6). No difference in the proportion of patients with moderate/severe pain was found between MP/placebo groups at 24 hours (67% and 74%, χ2 = .2, P = .63, odds ratio = .7, 95% confidence interval = .2-2.8) or at 48 hours (57% and 68%, χ2 = .5, P = .46, odds ratio = .6, 95% confidence interval = .2-2.3), and no difference between groups in postoperative sensitization was found (P > .4) despite reduced preoperative intra-articular inflammation (IL-6) in the MP group versus placebo (median change in IL-6 = -70 pg/mL, interquartile range = -466 to 0 vs. 32 pg/mL, interquartile range = -26 to 75, P = .029). Alternative central or peripheral analgesic interventions in this high-risk group are required.Peripherally driven inflammatory pain and nociceptive changes before TKA has been suggested to be a cause for increased acute postoperative pain. However, preoperative intra-articular MP in patients with high pain osteoarthritis and sensitization did not reduce acute post-TKA pain or sensitization despite a preoperative reduction of intra-articular inflammatory markers." @default.
• W2749677185 created "2017-08-31" @default.
• W2749677185 creator A5014139265 @default.
• W2749677185 creator A5021293594 @default.
• W2749677185 creator A5025881972 @default.
• W2749677185 creator A5052564716 @default.
• W2749677185 creator A5064091938 @default.
• W2749677185 creator A5077368833 @default.
• W2749677185 creator A5082545482 @default.
• W2749677185 date "2017-12-01" @default.
• W2749677185 modified "2023-10-14" @default.
• W2749677185 title "The Effect of Preoperative Intra-Articular Methylprednisolone on Pain After TKA: A Randomized Double-Blinded Placebo Controlled Trial in Patients With High-Pain Knee Osteoarthritis and Sensitization" @default.
• W2749677185 cites W1547787343 @default.
• W2749677185 cites W1607335194 @default.
• W2749677185 cites W1702269295 @default.
• W2749677185 cites W1718779047 @default.
• W2749677185 cites W1925599086 @default.
• W2749677185 cites W1968481626 @default.
• W2749677185 cites W1969443752 @default.
• W2749677185 cites W1971877019 @default.
• W2749677185 cites W1972622490 @default.
• W2749677185 cites W1978519915 @default.
• W2749677185 cites W1990076794 @default.
• W2749677185 cites W1995786136 @default.
• W2749677185 cites W2009024168 @default.
• W2749677185 cites W2010097647 @default.
• W2749677185 cites W2011562544 @default.
• W2749677185 cites W2013590819 @default.
• W2749677185 cites W2017805692 @default.
• W2749677185 cites W2029468390 @default.
• W2749677185 cites W2036601288 @default.
• W2749677185 cites W2045756991 @default.
• W2749677185 cites W2051342343 @default.
• W2749677185 cites W2053410759 @default.
• W2749677185 cites W2054930877 @default.
• W2749677185 cites W2055660712 @default.
• W2749677185 cites W2059761199 @default.
• W2749677185 cites W2064023939 @default.
• W2749677185 cites W2066640977 @default.
• W2749677185 cites W2071441738 @default.
• W2749677185 cites W2073951287 @default.
• W2749677185 cites W2081695825 @default.
• W2749677185 cites W2106678582 @default.
• W2749677185 cites W2107855857 @default.
• W2749677185 cites W2108174506 @default.
• W2749677185 cites W2116230226 @default.
• W2749677185 cites W2121802438 @default.
• W2749677185 cites W2122621722 @default.
• W2749677185 cites W2125837225 @default.
• W2749677185 cites W2129098356 @default.
• W2749677185 cites W2130141996 @default.
• W2749677185 cites W2135724744 @default.
• W2749677185 cites W2142941764 @default.
• W2749677185 cites W2163994645 @default.
• W2749677185 cites W2166281097 @default.
• W2749677185 cites W2221680155 @default.
• W2749677185 cites W2250440276 @default.
• W2749677185 cites W2269357000 @default.
• W2749677185 cites W2310101643 @default.
• W2749677185 cites W2465567709 @default.
• W2749677185 cites W2504876810 @default.
• W2749677185 cites W2518740841 @default.
• W2749677185 cites W2527861074 @default.
• W2749677185 cites W2559959729 @default.
• W2749677185 cites W2586481052 @default.
• W2749677185 cites W2614751560 @default.
• W2749677185 doi "https://doi.org/10.1016/j.jpain.2017.07.010" @default.
• W2749677185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28842370" @default.
• W2749677185 hasPublicationYear "2017" @default.
• W2749677185 type Work @default.
• W2749677185 sameAs 2749677185 @default.
• W2749677185 citedByCount "18" @default.
• W2749677185 countsByYear W27496771852018 @default.
• W2749677185 countsByYear W27496771852019 @default.
• W2749677185 countsByYear W27496771852020 @default.
• W2749677185 countsByYear W27496771852021 @default.
• W2749677185 countsByYear W27496771852022 @default.
• W2749677185 crossrefType "journal-article" @default.
• W2749677185 hasAuthorship W2749677185A5014139265 @default.
• W2749677185 hasAuthorship W2749677185A5021293594 @default.
• W2749677185 hasAuthorship W2749677185A5025881972 @default.
• W2749677185 hasAuthorship W2749677185A5052564716 @default.
• W2749677185 hasAuthorship W2749677185A5064091938 @default.
• W2749677185 hasAuthorship W2749677185A5077368833 @default.
• W2749677185 hasAuthorship W2749677185A5082545482 @default.
• W2749677185 hasBestOaLocation W27496771851 @default.
• W2749677185 hasConcept C119060515 @default.
• W2749677185 hasConcept C126322002 @default.
• W2749677185 hasConcept C141071460 @default.
• W2749677185 hasConcept C142724271 @default.
• W2749677185 hasConcept C156957248 @default.
• W2749677185 hasConcept C168563851 @default.
• W2749677185 hasConcept C204787440 @default.
• W2749677185 hasConcept C27081682 @default.
• W2749677185 hasConcept C2776164576 @default.
• W2749677185 hasConcept C2780372218 @default.
• W2749677185 hasConcept C2780820201 @default.
• W2749677185 hasConcept C42219234 @default.

• next