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• W2749694767 abstract "Abstract HLA ‐G is a non‐classical class I HLA antigen, normally expressed in high levels only on extravillous cytotrophoblast. It has immunosuppressive properties in pregnancy and has also been found to be upregulated on leucocytes in viral infection. In this study, proportions of all leucocyte subsets expressing HLA ‐G were found to be low in healthy subjects positive or negative for cytomegalovirus ( CMV ). Significantly greater proportions of CD 4+ CD 69+ and CD 56+ T cells expressed HLA ‐G compared to other T cells. However, following stimulation with CMV antigens or intact CMV , proportions of CD 4+, CD 8+, CD 69+ and CD 56+ T cells, and also B cells expressing HLA ‐G, were significantly increased in CMV + subjects. Despite some subjects having alleles of HLA ‐G associated with high levels of expression, no relationship was found between HLA ‐G genotype and expression levels. Purified B cells from CMV + subjects stimulated in mixed culture with CMV antigens showed significantly increased HLA ‐G mRNA expression by real‐time polymerase chain reaction. Serum levels of soluble HLA ‐G were similar in CMV − and CMV + subjects but levels in culture supernatants were significantly higher in cells from CMV + than from CMV − subjects stimulated with CMV antigens. The HLA ‐G ligand KIR 2 DL 4 was mainly expressed on NK cells and CD 56+ T cells with no differences between CMV + and CMV − subjects. Following stimulation with IL ‐2, an increase in the proportion of CD 56+ T cells positive for KIR 2 DL 4 was found, together with a significant decrease in CD 56dim CD 16+ NK cells. The results show that CMV influences HLA ‐G expression in healthy subjects and may contribute to viral immune evasion." @default.
• W2749694767 created "2017-08-31" @default.
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• W2749694767 date "2017-09-19" @default.
• W2749694767 modified "2023-10-03" @default.
• W2749694767 title "The Influence of Cytomegalovirus on Expression of HLA-G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets" @default.
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• W2749694767 doi "https://doi.org/10.1111/sji.12594" @default.
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