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- W2749853997 abstract "Abstract Background Pseudomonas aeruginosa (PA), one of the species of the ESKAPE pathogens that are known to “escape” the effects of many antimicrobials, is often difficult to treat. Ceftolozane-tazobactam (C/T) is an anti-pseudomonal cephalosporin/β-lactamase inhibitor recently approved by FDA and EMEA. We examined its activity against global clinical isolates of PA, including isolates non-susceptible (NS, intermediate or resistant) to other agents. Methods In 2016, 158 hospitals in 51 countries collected 5533 PA from intra-abdominal (IAI), urinary (UTI), and respiratory tract infections (RTI). MICs were determined using CLSI broth microdilution and interpreted with both CLSI and EUCAST breakpoints, as the susceptible breakpoints for C/T, cefepime (FEP), meropenem (MEM), and piperacillin-tazobactam (P/T) are the same using both criteria. Results Overall regional susceptibility of PA to C/T, prevalence of FEP-NS, MEM- NS, and P/T- NS phenotypes, and susceptibility of these phenotypes to C/T are shown below: Conclusion Overall susceptibility to C/T ranged from 85% in Latin America to 98% in South Pacific. FEP-NS, MEM-NS, and P/T-NS isolates were least prevalent in South Pacific. C/T was active against these phenotypes in >80% of isolates in North America and South Pacific and against 62–73% of MEM-NS and P/T-NS isolates in all other regions except Latin America. Monitoring of C/T susceptibility to PA is warranted in light of increasing resistance to first line agents. Disclosures M. Hackel, IHMA: Employee, Salary; R. Badal, IHMA, Inc: Employee, Salary; K. Young, Merck: Employee and Shareholder, Dividends and Salary M. Motyl, Merck & Co., Inc.,: Employee, Salary" @default.
- W2749853997 created "2017-08-31" @default.
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- W2749853997 date "2017-01-01" @default.
- W2749853997 modified "2023-10-02" @default.
- W2749853997 title "Activity of Ceftolozane-Tazobactam Against Global Pseudomonas Aeruginosa and Non-Susceptible Phenotypes: SMART 2016" @default.
- W2749853997 doi "https://doi.org/10.1093/ofid/ofx163.940" @default.
- W2749853997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5631510" @default.
- W2749853997 hasPublicationYear "2017" @default.
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