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- W2749862912 abstract "The mechanism of health effects caused by organohalogen pollutants,e.g.,toxins from electronic waste (e-waste),is poorly understood.We supposed that microRNAs (miRNAs),an important post-transcriptional regulator,could play a role in this process.In this study,fasting peripheral blood samples were collected from residents living at an e-waste site in northern China and a nearby reference population.Concentrations of e-waste related organohalogen pollutants in plasma from the exposure group were higher than the corresponding measurement in the reference group.Correspondingly,sixty miRNAs in plasma showed > 2-fold change between the two groups in microarray analysis.Among them,miR-125a-5p was confirmed to be upregulated by qRT-PCR and its validated targets were enriched in responses to xenobiotics and cancer related pathways.Furthermore,significant positive correlations were found between levels of miR-125a-5p in plasma and reactive oxygen species (ROS) in polymorphonuclear neutrophil leuKocytes (P<0.05).These evidences suggested oxidative stress might be an intermediate between e-waste related POPs exposure and alteration of plasma miRNA." @default.
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- W2749862912 date "2016-01-01" @default.
- W2749862912 modified "2023-09-27" @default.
- W2749862912 title "MiR -125a -5p is Upregulated in Plasma of Residents from An Electronic Waste Recycling Site" @default.
- W2749862912 doi "https://doi.org/10.7524/aje.1673-5897.20151118001" @default.
- W2749862912 hasPublicationYear "2016" @default.
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