FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2749880506> ?p ?o ?g. }

• W2749880506 abstract "Smoking is a leading cause of numerous human disorders including lung cancer, chronic obstructive pulmonary disease, and atherosclerotic cardiovascular disease. The development of modified risk tobacco products (MRTPs) has been suggested as a possible way to reduce the risks of tobacco smoking by reducing exposure to cigarette smoke toxicants. This study is designed to investigate whether biomarkers of such exposure are reduced when smokers switch from smoking commercial cigarettes to using either a novel or a commercially-available tobacco heating product (THP).This study will assess biomarkers of exposure in current smokers who either remain smoking, switch to THP use, or quit all tobacco use completely, for 5 days. The study is an in-clinic (confinement) two-centre, randomised controlled clinical study with a forced-switching design. Subjects of either gender will be aged 23-55 years (minimum legal smoking age plus 3 years), of Japanese origin and with a verified smoking status (assessed by exhaled breath carbon monoxide and urinary cotinine levels). Subjects will have a usual brand cigarette within the International Organisation for Standardisation (ISO) tar band of 6-8 mg and will be judged to be healthy by medical history, physical examination, vital signs, electrocardiography (ECG), clinical biochemistry and lung function tests. The primary objective of this study is to assess changes within groups in selected biomarkers of exposure (BoE) and of biological effect (BoBE) after a forced switch from a commercial control cigarette to either a menthol or a non-menthol THP. Secondary objectives are to assess between-group differences, to determine nicotine pharmacokinetics for cigarettes and THPs, to assess subject's satisfaction with the study products, and to monitor additional endpoints related to safety and product use.Data from this study will advance our scientific understanding of the changes in exposure to cigarette smoke toxicants in smokers who switch to using a THP.UMIN000024988 (25th November 2016); ISRCTN14301360 (14th December 2016)." @default.
• W2749880506 created "2017-08-31" @default.
• W2749880506 creator A5002314156 @default.
• W2749880506 creator A5003606002 @default.
• W2749880506 creator A5007433796 @default.
• W2749880506 creator A5012132196 @default.
• W2749880506 creator A5016046647 @default.
• W2749880506 creator A5025333462 @default.
• W2749880506 creator A5043756859 @default.
• W2749880506 creator A5045521896 @default.
• W2749880506 creator A5062712587 @default.
• W2749880506 creator A5067371575 @default.
• W2749880506 creator A5071328529 @default.
• W2749880506 creator A5072494760 @default.
• W2749880506 creator A5085227618 @default.
• W2749880506 creator A5085577899 @default.
• W2749880506 creator A5085961761 @default.
• W2749880506 creator A5086522066 @default.
• W2749880506 date "2017-08-22" @default.
• W2749880506 modified "2023-09-23" @default.
• W2749880506 title "A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product" @default.
• W2749880506 cites W1447803706 @default.
• W2749880506 cites W1515115339 @default.
• W2749880506 cites W1976429029 @default.
• W2749880506 cites W1978962137 @default.
• W2749880506 cites W1988633497 @default.
• W2749880506 cites W1990685569 @default.
• W2749880506 cites W1999645889 @default.
• W2749880506 cites W2005069726 @default.
• W2749880506 cites W2010631276 @default.
• W2749880506 cites W2024107979 @default.
• W2749880506 cites W2059934851 @default.
• W2749880506 cites W2081043365 @default.
• W2749880506 cites W2081811812 @default.
• W2749880506 cites W2099970296 @default.
• W2749880506 cites W2100346673 @default.
• W2749880506 cites W2108678383 @default.
• W2749880506 cites W2118889939 @default.
• W2749880506 cites W2125078269 @default.
• W2749880506 cites W2129748624 @default.
• W2749880506 cites W2137599927 @default.
• W2749880506 cites W2141348739 @default.
• W2749880506 cites W2144465342 @default.
• W2749880506 cites W2146165275 @default.
• W2749880506 cites W2267264234 @default.
• W2749880506 cites W2274460868 @default.
• W2749880506 cites W2526016646 @default.
• W2749880506 cites W2559921624 @default.
• W2749880506 cites W274366881 @default.
• W2749880506 cites W4239550199 @default.
• W2749880506 cites W4254884066 @default.
• W2749880506 doi "https://doi.org/10.1186/s12889-017-4678-9" @default.
• W2749880506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5567437" @default.
• W2749880506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28830420" @default.
• W2749880506 hasPublicationYear "2017" @default.
• W2749880506 type Work @default.
• W2749880506 sameAs 2749880506 @default.
• W2749880506 citedByCount "20" @default.
• W2749880506 countsByYear W27498805062018 @default.
• W2749880506 countsByYear W27498805062019 @default.
• W2749880506 countsByYear W27498805062020 @default.
• W2749880506 countsByYear W27498805062021 @default.
• W2749880506 countsByYear W27498805062022 @default.
• W2749880506 countsByYear W27498805062023 @default.
• W2749880506 crossrefType "journal-article" @default.
• W2749880506 hasAuthorship W2749880506A5002314156 @default.
• W2749880506 hasAuthorship W2749880506A5003606002 @default.
• W2749880506 hasAuthorship W2749880506A5007433796 @default.
• W2749880506 hasAuthorship W2749880506A5012132196 @default.
• W2749880506 hasAuthorship W2749880506A5016046647 @default.
• W2749880506 hasAuthorship W2749880506A5025333462 @default.
• W2749880506 hasAuthorship W2749880506A5043756859 @default.
• W2749880506 hasAuthorship W2749880506A5045521896 @default.
• W2749880506 hasAuthorship W2749880506A5062712587 @default.
• W2749880506 hasAuthorship W2749880506A5067371575 @default.
• W2749880506 hasAuthorship W2749880506A5071328529 @default.
• W2749880506 hasAuthorship W2749880506A5072494760 @default.
• W2749880506 hasAuthorship W2749880506A5085227618 @default.
• W2749880506 hasAuthorship W2749880506A5085577899 @default.
• W2749880506 hasAuthorship W2749880506A5085961761 @default.
• W2749880506 hasAuthorship W2749880506A5086522066 @default.
• W2749880506 hasBestOaLocation W27498805061 @default.
• W2749880506 hasConcept C121332964 @default.
• W2749880506 hasConcept C126322002 @default.
• W2749880506 hasConcept C142724271 @default.
• W2749880506 hasConcept C153294291 @default.
• W2749880506 hasConcept C1862650 @default.
• W2749880506 hasConcept C2776281542 @default.
• W2749880506 hasConcept C2776319443 @default.
• W2749880506 hasConcept C2776970978 @default.
• W2749880506 hasConcept C2778355491 @default.
• W2749880506 hasConcept C2779547902 @default.
• W2749880506 hasConcept C3019085024 @default.
• W2749880506 hasConcept C58874564 @default.
• W2749880506 hasConcept C71924100 @default.
• W2749880506 hasConcept C98265973 @default.
• W2749880506 hasConcept C99454951 @default.
• W2749880506 hasConceptScore W2749880506C121332964 @default.
• W2749880506 hasConceptScore W2749880506C126322002 @default.
• W2749880506 hasConceptScore W2749880506C142724271 @default.

• next