FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2749898086> ?p ?o ?g. }

• W2749898086 endingPage "7033" @default.
• W2749898086 startingPage "7020" @default.
• W2749898086 abstract "Abstract Purpose: We aimed to characterize and target drug-tolerant BRCA1-deficient tumor cells that cause residual disease and subsequent tumor relapse. Experimental Design: We studied responses to various mono- and bifunctional alkylating agents in a genetically engineered mouse model for BRCA1/p53-mutant breast cancer. Because of the large intragenic deletion of the Brca1 gene, no restoration of BRCA1 function is possible, and therefore, no BRCA1-dependent acquired resistance occurs. To characterize the cell-cycle stage from which Brca1−/−;p53−/− mammary tumors arise after cisplatin treatment, we introduced the fluorescent ubiquitination-based cell-cycle indicator (FUCCI) construct into the tumor cells. Results: Despite repeated sensitivity to the MTD of platinum drugs, the Brca1-mutated mammary tumors are not eradicated, not even by a frequent dosing schedule. We show that relapse comes from single-nucleated cells delaying entry into the S-phase. Such slowly cycling cells, which are present within the drug-naïve tumors, are enriched in tumor remnants. Using the FUCCI construct, we identified nonfluorescent G0-like cells as the population most tolerant to platinum drugs. Intriguingly, these cells are more sensitive to the DNA-crosslinking agent nimustine, resulting in an increased number of multinucleated cells that lack clonogenicity. This is consistent with our in vivo finding that the nimustine MTD, among several alkylating agents, is the most effective in eradicating Brca1-mutated mouse mammary tumors. Conclusions: Our data show that targeting G0-like cells is crucial for the eradication of BRCA1/p53–deficient tumor cells. This can be achieved with selected alkylating agents such as nimustine. Clin Cancer Res; 23(22); 7020–33. ©2017 AACR." @default.
• W2749898086 created "2017-08-31" @default.
• W2749898086 creator A5003267425 @default.
• W2749898086 creator A5017173720 @default.
• W2749898086 creator A5033897111 @default.
• W2749898086 creator A5035972976 @default.
• W2749898086 creator A5040945337 @default.
• W2749898086 creator A5049270608 @default.
• W2749898086 creator A5052578730 @default.
• W2749898086 creator A5060054431 @default.
• W2749898086 creator A5061340130 @default.
• W2749898086 creator A5073106472 @default.
• W2749898086 creator A5086723762 @default.
• W2749898086 date "2017-11-14" @default.
• W2749898086 modified "2023-10-18" @default.
• W2749898086 title "Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice" @default.
• W2749898086 cites W1968540963 @default.
• W2749898086 cites W1970578083 @default.
• W2749898086 cites W1973560717 @default.
• W2749898086 cites W1974693247 @default.
• W2749898086 cites W1986906826 @default.
• W2749898086 cites W1989996784 @default.
• W2749898086 cites W1992661182 @default.
• W2749898086 cites W1996435746 @default.
• W2749898086 cites W2004125597 @default.
• W2749898086 cites W2014599726 @default.
• W2749898086 cites W2015360671 @default.
• W2749898086 cites W2038226174 @default.
• W2749898086 cites W2040290218 @default.
• W2749898086 cites W2041594739 @default.
• W2749898086 cites W2043610941 @default.
• W2749898086 cites W2049812251 @default.
• W2749898086 cites W2051808614 @default.
• W2749898086 cites W2054737033 @default.
• W2749898086 cites W2094144162 @default.
• W2749898086 cites W2096136751 @default.
• W2749898086 cites W2096380982 @default.
• W2749898086 cites W2103177188 @default.
• W2749898086 cites W2106391833 @default.
• W2749898086 cites W2107525151 @default.
• W2749898086 cites W2133258471 @default.
• W2749898086 cites W2133632121 @default.
• W2749898086 cites W2134892897 @default.
• W2749898086 cites W2137935883 @default.
• W2749898086 cites W2139718226 @default.
• W2749898086 cites W2145200068 @default.
• W2749898086 cites W2149207987 @default.
• W2749898086 cites W2151864343 @default.
• W2749898086 cites W2160113753 @default.
• W2749898086 cites W2161103689 @default.
• W2749898086 cites W2164660906 @default.
• W2749898086 cites W2168946040 @default.
• W2749898086 cites W2473878031 @default.
• W2749898086 cites W2476568892 @default.
• W2749898086 cites W2488197626 @default.
• W2749898086 cites W2562944419 @default.
• W2749898086 cites W2952670656 @default.
• W2749898086 cites W4250668107 @default.
• W2749898086 doi "https://doi.org/10.1158/1078-0432.ccr-17-1279" @default.
• W2749898086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28821557" @default.
• W2749898086 hasPublicationYear "2017" @default.
• W2749898086 type Work @default.
• W2749898086 sameAs 2749898086 @default.
• W2749898086 citedByCount "18" @default.
• W2749898086 countsByYear W27498980862017 @default.
• W2749898086 countsByYear W27498980862018 @default.
• W2749898086 countsByYear W27498980862019 @default.
• W2749898086 countsByYear W27498980862020 @default.
• W2749898086 countsByYear W27498980862021 @default.
• W2749898086 countsByYear W27498980862022 @default.
• W2749898086 countsByYear W27498980862023 @default.
• W2749898086 crossrefType "journal-article" @default.
• W2749898086 hasAuthorship W2749898086A5003267425 @default.
• W2749898086 hasAuthorship W2749898086A5017173720 @default.
• W2749898086 hasAuthorship W2749898086A5033897111 @default.
• W2749898086 hasAuthorship W2749898086A5035972976 @default.
• W2749898086 hasAuthorship W2749898086A5040945337 @default.
• W2749898086 hasAuthorship W2749898086A5049270608 @default.
• W2749898086 hasAuthorship W2749898086A5052578730 @default.
• W2749898086 hasAuthorship W2749898086A5060054431 @default.
• W2749898086 hasAuthorship W2749898086A5061340130 @default.
• W2749898086 hasAuthorship W2749898086A5073106472 @default.
• W2749898086 hasAuthorship W2749898086A5086723762 @default.
• W2749898086 hasBestOaLocation W27498980861 @default.
• W2749898086 hasConcept C121608353 @default.
• W2749898086 hasConcept C136403682 @default.
• W2749898086 hasConcept C154317977 @default.
• W2749898086 hasConcept C202751555 @default.
• W2749898086 hasConcept C207001950 @default.
• W2749898086 hasConcept C2776187077 @default.
• W2749898086 hasConcept C2776694085 @default.
• W2749898086 hasConcept C2778239845 @default.
• W2749898086 hasConcept C2908647359 @default.
• W2749898086 hasConcept C29537977 @default.
• W2749898086 hasConcept C502942594 @default.
• W2749898086 hasConcept C530470458 @default.
• W2749898086 hasConcept C54355233 @default.
• W2749898086 hasConcept C71924100 @default.

• next