Matches in SemOpenAlex for { <https://semopenalex.org/work/W2750019921> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2750019921 abstract "Background: Magnetic resonance imaging (MRI) can provide a reference for tumor treatment and its quantitative parameters can serve as imaging indicators that reflect tumor angiogenesis and vascularity. Kanglaite (KLT) has therapeutic effects on cancers. In this study, DCE-MRI was used to investigate its application in evaluating KLT anti-colorectal cancer. Objectives: Evaluating the efficacy of Kanglaite (KLT) injection for treatment of colorectal cancer with dynamic contrast-enhanced MRI (DCE-MRI) parameters. Methods: This study was an experimental study. The 20 successfully modeled nude mice were randomly assigned to 2 groups: blank control group (n = 10) and the KLT injection group (n = 10). The research protocol was approved by the ethics committee of the second affiliated hospital of Xinjiang medical university (protocol NO: 20140216-12) in 2015. A subcutaneous xenograft colorectal tumor model was subjected to KLT treatment. DCE-MRI obtain the parameters including Ktrans, Ve, Kep, Vp, immunohistochemical staining measure microvascular density (MVD), levels of vascular endothelial growth factor (VEGF), and proliferating cell nuclear antigen (PCNA). Results: Compared to the blank control, the volume of tumor in the KLT group markedly reduced by 49%. 48 hours after, compared to the blank control, the Ktrans (0.028 ± 0.009 vs 0.012 ± 0.006), Ve (0.312 ± 0.089 vs 0.287 ± 0.037), and Kep values (0.321 ± 0.056 vs 0.577 ± 0.033) decreased in KLT group (P < 0.05). In contrast, the Vp value (0.094 ± 0.037 vs 0.043 ± 0.017) was significantly elevated in the KLT group (P < 0.05). There is a correlation between Ktrans, Kep and VEGF score, MVD count, and PCNA score. Conclusions: The parameters of DCE-MRI may be used as imaging biomarkers for assessing the status of tumor-bearing vasculatures and provide a basis for evaluating the efficacy of anti-tumor drugs." @default.
- W2750019921 created "2017-08-31" @default.
- W2750019921 creator A5014603317 @default.
- W2750019921 creator A5037694066 @default.
- W2750019921 creator A5052716698 @default.
- W2750019921 date "2017-08-22" @default.
- W2750019921 modified "2023-10-18" @default.
- W2750019921 title "Application of Dynamic Contrast-Enhanced MRI in the Therapeutic Evaluation of the Chinese Medicine Kanglaite in Treating Colorectal Cancer" @default.
- W2750019921 cites W1968711241 @default.
- W2750019921 cites W1970877429 @default.
- W2750019921 cites W1974210580 @default.
- W2750019921 cites W2016737587 @default.
- W2750019921 cites W2021196585 @default.
- W2750019921 cites W2044075939 @default.
- W2750019921 cites W2054627582 @default.
- W2750019921 cites W2056782707 @default.
- W2750019921 cites W2097309933 @default.
- W2750019921 cites W2109508808 @default.
- W2750019921 cites W2153596203 @default.
- W2750019921 cites W2316784803 @default.
- W2750019921 cites W2317880662 @default.
- W2750019921 doi "https://doi.org/10.5812/ircmj.59940" @default.
- W2750019921 hasPublicationYear "2017" @default.
- W2750019921 type Work @default.
- W2750019921 sameAs 2750019921 @default.
- W2750019921 citedByCount "0" @default.
- W2750019921 crossrefType "journal-article" @default.
- W2750019921 hasAuthorship W2750019921A5014603317 @default.
- W2750019921 hasAuthorship W2750019921A5037694066 @default.
- W2750019921 hasAuthorship W2750019921A5052716698 @default.
- W2750019921 hasBestOaLocation W27500199211 @default.
- W2750019921 hasConcept C121608353 @default.
- W2750019921 hasConcept C126322002 @default.
- W2750019921 hasConcept C126838900 @default.
- W2750019921 hasConcept C126894567 @default.
- W2750019921 hasConcept C142724271 @default.
- W2750019921 hasConcept C143409427 @default.
- W2750019921 hasConcept C167734588 @default.
- W2750019921 hasConcept C178596483 @default.
- W2750019921 hasConcept C204232928 @default.
- W2750019921 hasConcept C2777025900 @default.
- W2750019921 hasConcept C2780394083 @default.
- W2750019921 hasConcept C2989005 @default.
- W2750019921 hasConcept C2994142346 @default.
- W2750019921 hasConcept C34688535 @default.
- W2750019921 hasConcept C526805850 @default.
- W2750019921 hasConcept C71924100 @default.
- W2750019921 hasConceptScore W2750019921C121608353 @default.
- W2750019921 hasConceptScore W2750019921C126322002 @default.
- W2750019921 hasConceptScore W2750019921C126838900 @default.
- W2750019921 hasConceptScore W2750019921C126894567 @default.
- W2750019921 hasConceptScore W2750019921C142724271 @default.
- W2750019921 hasConceptScore W2750019921C143409427 @default.
- W2750019921 hasConceptScore W2750019921C167734588 @default.
- W2750019921 hasConceptScore W2750019921C178596483 @default.
- W2750019921 hasConceptScore W2750019921C204232928 @default.
- W2750019921 hasConceptScore W2750019921C2777025900 @default.
- W2750019921 hasConceptScore W2750019921C2780394083 @default.
- W2750019921 hasConceptScore W2750019921C2989005 @default.
- W2750019921 hasConceptScore W2750019921C2994142346 @default.
- W2750019921 hasConceptScore W2750019921C34688535 @default.
- W2750019921 hasConceptScore W2750019921C526805850 @default.
- W2750019921 hasConceptScore W2750019921C71924100 @default.
- W2750019921 hasLocation W27500199211 @default.
- W2750019921 hasOpenAccess W2750019921 @default.
- W2750019921 hasPrimaryLocation W27500199211 @default.
- W2750019921 hasRelatedWork W2006474542 @default.
- W2750019921 hasRelatedWork W2037101735 @default.
- W2750019921 hasRelatedWork W2040502369 @default.
- W2750019921 hasRelatedWork W2074151813 @default.
- W2750019921 hasRelatedWork W2088017009 @default.
- W2750019921 hasRelatedWork W2095494759 @default.
- W2750019921 hasRelatedWork W2382070292 @default.
- W2750019921 hasRelatedWork W2394059483 @default.
- W2750019921 hasRelatedWork W2515578284 @default.
- W2750019921 hasRelatedWork W2556391607 @default.
- W2750019921 hasRelatedWork W2557732770 @default.
- W2750019921 hasRelatedWork W2586308671 @default.
- W2750019921 hasRelatedWork W2801050032 @default.
- W2750019921 hasRelatedWork W2904438763 @default.
- W2750019921 hasRelatedWork W2938059410 @default.
- W2750019921 hasRelatedWork W2946993447 @default.
- W2750019921 hasRelatedWork W2969896729 @default.
- W2750019921 hasRelatedWork W3030860263 @default.
- W2750019921 hasRelatedWork W3184616252 @default.
- W2750019921 hasRelatedWork W3197438990 @default.
- W2750019921 isParatext "false" @default.
- W2750019921 isRetracted "false" @default.
- W2750019921 magId "2750019921" @default.
- W2750019921 workType "article" @default.