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- W2750077507 endingPage "177" @default.
- W2750077507 startingPage "162" @default.
- W2750077507 abstract "Cocrystals are crystalline single phase materials composed of two or more different molecular and/or ionic compounds generally in a stoichiometric ratio which are neither solvates nor simple salts. If one of the components is an active pharmaceutical ingredient (API), the term pharmaceutical cocrystal is often used. There is a growing interest among drug development scientists in exploring cocrystals, as means to address physicochemical, biopharmaceutical and mechanical properties and expand solid form diversity of the API. Conventionally, coformers are selected based on crystal engineering principles, and the equimolar mixtures of API and coformers are subjected to solution-based crystallization that are commonly employed in polymorph and salt screening. However, the availability of new knowledge on cocrystal phase behaviour in solid state and solutions has spurred the development and implementation of more rational experimental cocrystal screening as well as scale-up methods. This review aims to provide overview of commonly employed solid form screening techniques in drug development with an emphasis on cocrystal screening methodologies. The latest developments in understanding and the use of cocrystal phase diagrams in both screening and solution based scale-up methods are also presented. Final section is devoted to reviewing the state of the art research covering solution based scale-up cocrystallization process for different cocrystals besides more recent continuous crystallization methods." @default.
- W2750077507 created "2017-08-31" @default.
- W2750077507 creator A5012429451 @default.
- W2750077507 creator A5058817027 @default.
- W2750077507 creator A5089470409 @default.
- W2750077507 creator A5090614750 @default.
- W2750077507 date "2017-08-01" @default.
- W2750077507 modified "2023-10-01" @default.
- W2750077507 title "Experimental cocrystal screening and solution based scale-up cocrystallization methods" @default.
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