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- W2750243986 abstract "Abstract Asymmetric cation‐binding catalysis, in principle, can generate “chiral” anionic nucleophiles, where the counter cations are coordinated within chiral environments. Nitrogen nucleophiles are intrinsically basic, therefore, its use as nucleophiles is often challenging and limiting the scope of the reaction. Particularly, a formation of configurationally labile aminal centers with alkyl substituents has been a formidable challenge due to the enamine/imine equilibrium of electrophilic substrates. Herein, we report enantioselective nucleophilic addition reactions of potassium phthalimides to Boc‐protected alkyl‐ and aryl‐substituted α‐amido sulfones. In situ generated imines smoothly reacted with the nitrogen nucleophiles to corresponding aminals with good to excellent enantioselectivitiy under mild reaction conditions. In addition, transformation of aminal products gave biologically relevant pyrrolidinone‐fused hexahydropyrimidine scaffold with excellent stereoselectivity and good yield." @default.
- W2750243986 created "2017-08-31" @default.
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- W2750243986 date "2017-12-05" @default.
- W2750243986 modified "2023-10-16" @default.
- W2750243986 title "Asymmetric Aminalization via Cation-Binding Catalysis" @default.
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- W2750243986 doi "https://doi.org/10.1002/chem.201703800" @default.
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