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- W2750275119 abstract "Intermediate conductance calcium-activated potassium channels (KCa3.1) have been recently implicated in pain processing. However, the functional role and localization of KCa3.1 in the nociceptive system are largely unknown. We here characterized the behavior of mice lacking KCa3.1 (KCa3.1-/-) in various pain models and analyzed the expression pattern of KCa3.1 in dorsal root ganglia (DRG) and the spinal cord. KCa3.1-/- mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM-34. In situ hybridization experiments detected KCa3.1 in most DRG satellite glial cells, in a minority of DRG neurons, and in ependymal cells lining the central canal of the spinal cord. Together, our data point to a specific inhibitory role of KCa3.1 for the processing of noxious chemical stimuli." @default.
- W2750275119 created "2017-08-31" @default.
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- W2750275119 date "2017-10-01" @default.
- W2750275119 modified "2023-10-14" @default.
- W2750275119 title "KCa3.1 channels modulate the processing of noxious chemical stimuli in mice" @default.
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- W2750275119 cites W1968217697 @default.
- W2750275119 cites W1971823419 @default.
- W2750275119 cites W1973235352 @default.
- W2750275119 cites W1974360350 @default.
- W2750275119 cites W1975553420 @default.
- W2750275119 cites W1977704347 @default.
- W2750275119 cites W1984494120 @default.
- W2750275119 cites W1985850982 @default.
- W2750275119 cites W1988635251 @default.
- W2750275119 cites W1991083159 @default.
- W2750275119 cites W1992875946 @default.
- W2750275119 cites W1993231626 @default.
- W2750275119 cites W1993652945 @default.
- W2750275119 cites W1994982783 @default.
- W2750275119 cites W1996333163 @default.
- W2750275119 cites W2001476096 @default.
- W2750275119 cites W2014185236 @default.
- W2750275119 cites W2017287657 @default.
- W2750275119 cites W2017515163 @default.
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- W2750275119 cites W2027210843 @default.
- W2750275119 cites W2033841097 @default.
- W2750275119 cites W2038693417 @default.
- W2750275119 cites W2039246411 @default.
- W2750275119 cites W2040831152 @default.
- W2750275119 cites W2042653860 @default.
- W2750275119 cites W2042927086 @default.
- W2750275119 cites W2043765720 @default.
- W2750275119 cites W2044495359 @default.
- W2750275119 cites W2047010161 @default.
- W2750275119 cites W2047985837 @default.
- W2750275119 cites W2048385760 @default.
- W2750275119 cites W2049627978 @default.
- W2750275119 cites W2050533098 @default.
- W2750275119 cites W2052604373 @default.
- W2750275119 cites W2053682262 @default.
- W2750275119 cites W2054657321 @default.
- W2750275119 cites W2058238554 @default.
- W2750275119 cites W2060331633 @default.
- W2750275119 cites W2062997220 @default.
- W2750275119 cites W2067228292 @default.
- W2750275119 cites W2070069129 @default.
- W2750275119 cites W2076234525 @default.
- W2750275119 cites W2076586539 @default.
- W2750275119 cites W2077489086 @default.
- W2750275119 cites W2080077963 @default.
- W2750275119 cites W2081797094 @default.
- W2750275119 cites W2083855520 @default.
- W2750275119 cites W2085502426 @default.
- W2750275119 cites W2086501301 @default.
- W2750275119 cites W2092858995 @default.
- W2750275119 cites W2096242779 @default.
- W2750275119 cites W2126436584 @default.
- W2750275119 cites W2128172681 @default.
- W2750275119 cites W2133490942 @default.
- W2750275119 cites W2134557769 @default.
- W2750275119 cites W2137435338 @default.
- W2750275119 cites W2139779919 @default.
- W2750275119 cites W2153164502 @default.
- W2750275119 cites W2159477730 @default.
- W2750275119 cites W2161387630 @default.
- W2750275119 cites W2164837602 @default.
- W2750275119 cites W2168251051 @default.
- W2750275119 cites W2344346098 @default.
- W2750275119 cites W2395336248 @default.
- W2750275119 cites W2409924309 @default.
- W2750275119 cites W2411619501 @default.
- W2750275119 cites W2418597439 @default.
- W2750275119 cites W2511823098 @default.
- W2750275119 cites W2552124266 @default.
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- W2750275119 doi "https://doi.org/10.1016/j.neuropharm.2017.08.021" @default.
- W2750275119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28823609" @default.
- W2750275119 hasPublicationYear "2017" @default.
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