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- W2750369261 abstract "Objective To explore the relationships among the occurrence ofteaticular dysgenesis syndrome with hypospadias and cryptorchidism,the polymorphic androgen-receptor CAG repeat and associated perinatal factors.Methods Blood samples were collected from 60 hypospadias,32 cryptorchidism (unilatcral 29 and bilateral 3,6 of them combined with hypospadias) and 70 normal boys as control between May 2009 and Dec 2010.CAG repeat lengths of androgen receptor were measured.The perinatal data collected included birth weight and gestational age; mother's age,history of tocolysis in early trimester (the use of progesterone),assisted reproduction,mother's occupation,habitation and history of gestational hypertension.All data were statistically analyzed.Results The CAG repeat length of hypospadias and cryptorchidism were significantly longer than the control (P =0.008 and 0.028 respectively).Low birth weight of infants (P =0.003),mother's age (P =0.007) and the use of progesterone (P =0.000) were found to be risk factors for hypospadias.Mother's age (P =0.003)and agriculturalactivities (P =0.017) were risk factors for cryptorchidism.Conclusions The occurrence oftesticular dysgenesis syndrome is associated with multiple factors.The AR gene CAG repeat length,low birth weight,young mother,especially exposure to estrogen,anti-androgen substances,such as progesterone and pesticide all contribute to an increased risk of the occurrence of testicular dysgenesis syndrome.Key words: Testis; Hypospadias; Cryptorchidism; Androgen receptors; Perinatal factor" @default.
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- W2750369261 date "2012-05-15" @default.
- W2750369261 modified "2023-09-23" @default.
- W2750369261 title "Study on the relationship among testicular dysgenesis syndrome, androgen receptor gene polymorphism and associated perinatal factors" @default.
- W2750369261 doi "https://doi.org/10.3760/cma.j.issn.0253-3006.2012.05.012" @default.
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