FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2750451567> ?p ?o ?g. }

• W2750451567 endingPage "632" @default.
• W2750451567 startingPage "625" @default.
• W2750451567 abstract "The concept that excess pulsation in cerebral arteries might be involved at the early stage of dementia is based on the results of studies on aorta stiffness. In these studies, aorta stiffness is cross-sectionally associated with cognitive impairment and longitudinally related to cognitive decline in non-demented subjects. However, a direct measure of cerebral artery pulsatility is absent in the literature. We aimed to investigate the associations between cerebral artery pulsatility and (1) different cognitive-domains and (2) conversion to dementia in non-demented individuals at the prodromal-stage of Alzheimer's disease (AD). Non-demented individuals with subjective memory decline or mild cognitive impairment were included. Neuropsychological tests at baseline and cognitive status at 6 years were evaluated. Cerebral pulsatility was assessed in the middle cerebral artery (MCA) and posterior cerebral artery by transcranial color-coded sonography. Multivariate-analyses of 79 subjects with robust acoustic windows showed that increased pulsatility in cerebral arteries was significantly associated with impairment in corresponding cognitive domains. Analyses in 54 subjects who completed 6-year follow up revealed that high left MCA pulsation (pulsatility index≥1.1) independently predicted conversion to AD with an odds-ratio of 11.2. Our results demonstrate the spatio-temporal relationship between increased cerebral artery pulsation and cognitive impairment and suggest that increased cerebrovascular pulsation might be involved in the early pathogenesis of AD. Cerebrovascular pulsation may be a therapeutic target to prevent/delay AD onset. Future studies with other AD biomarkers and animal/cell models of increased vascular-pulsation are needed to elucidate the mechanisms by which cerebrovascular pulsatile injury initiates or precipitates neurodegeneration in AD." @default.
• W2750451567 created "2017-08-31" @default.
• W2750451567 creator A5002339856 @default.
• W2750451567 creator A5010804567 @default.
• W2750451567 creator A5026558728 @default.
• W2750451567 creator A5056534493 @default.
• W2750451567 date "2017-09-18" @default.
• W2750451567 modified "2023-10-18" @default.
• W2750451567 title "Cerebral Artery Pulsatility is Associated with Cognitive Impairment and Predicts Dementia in Individuals with Subjective Memory Decline or Mild Cognitive Impairment" @default.
• W2750451567 cites W1544359545 @default.
• W2750451567 cites W1847168837 @default.
• W2750451567 cites W1985894359 @default.
• W2750451567 cites W1987804548 @default.
• W2750451567 cites W1997482849 @default.
• W2750451567 cites W2008641148 @default.
• W2750451567 cites W2024034758 @default.
• W2750451567 cites W2027439132 @default.
• W2750451567 cites W2028507273 @default.
• W2750451567 cites W2029896342 @default.
• W2750451567 cites W2031601895 @default.
• W2750451567 cites W2034897558 @default.
• W2750451567 cites W2043522411 @default.
• W2750451567 cites W2051064550 @default.
• W2750451567 cites W2054057072 @default.
• W2750451567 cites W2055048118 @default.
• W2750451567 cites W2088342107 @default.
• W2750451567 cites W2129497119 @default.
• W2750451567 cites W2136728805 @default.
• W2750451567 cites W2140573529 @default.
• W2750451567 cites W2144437121 @default.
• W2750451567 cites W2155252568 @default.
• W2750451567 cites W2163710334 @default.
• W2750451567 cites W2167840686 @default.
• W2750451567 cites W2170116902 @default.
• W2750451567 cites W2199925433 @default.
• W2750451567 cites W2246007286 @default.
• W2750451567 cites W2275637221 @default.
• W2750451567 cites W2283957277 @default.
• W2750451567 cites W2531454303 @default.
• W2750451567 cites W2559033317 @default.
• W2750451567 cites W2569098370 @default.
• W2750451567 cites W2573101079 @default.
• W2750451567 cites W2583080338 @default.
• W2750451567 cites W32787667 @default.
• W2750451567 cites W4230870013 @default.
• W2750451567 cites W4241883936 @default.
• W2750451567 doi "https://doi.org/10.3233/jad-170349" @default.
• W2750451567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28826186" @default.
• W2750451567 hasPublicationYear "2017" @default.
• W2750451567 type Work @default.
• W2750451567 sameAs 2750451567 @default.
• W2750451567 citedByCount "33" @default.
• W2750451567 countsByYear W27504515672018 @default.
• W2750451567 countsByYear W27504515672019 @default.
• W2750451567 countsByYear W27504515672020 @default.
• W2750451567 countsByYear W27504515672021 @default.
• W2750451567 countsByYear W27504515672022 @default.
• W2750451567 countsByYear W27504515672023 @default.
• W2750451567 crossrefType "journal-article" @default.
• W2750451567 hasAuthorship W2750451567A5002339856 @default.
• W2750451567 hasAuthorship W2750451567A5010804567 @default.
• W2750451567 hasAuthorship W2750451567A5026558728 @default.
• W2750451567 hasAuthorship W2750451567A5056534493 @default.
• W2750451567 hasConcept C126322002 @default.
• W2750451567 hasConcept C15744967 @default.
• W2750451567 hasConcept C164705383 @default.
• W2750451567 hasConcept C169760540 @default.
• W2750451567 hasConcept C169900460 @default.
• W2750451567 hasConcept C171614378 @default.
• W2750451567 hasConcept C2775841333 @default.
• W2750451567 hasConcept C2775850156 @default.
• W2750451567 hasConcept C2777031167 @default.
• W2750451567 hasConcept C2778394091 @default.
• W2750451567 hasConcept C2779134260 @default.
• W2750451567 hasConcept C2779483572 @default.
• W2750451567 hasConcept C2984863031 @default.
• W2750451567 hasConcept C541997718 @default.
• W2750451567 hasConcept C71924100 @default.
• W2750451567 hasConcept C84393581 @default.
• W2750451567 hasConceptScore W2750451567C126322002 @default.
• W2750451567 hasConceptScore W2750451567C15744967 @default.
• W2750451567 hasConceptScore W2750451567C164705383 @default.
• W2750451567 hasConceptScore W2750451567C169760540 @default.
• W2750451567 hasConceptScore W2750451567C169900460 @default.
• W2750451567 hasConceptScore W2750451567C171614378 @default.
• W2750451567 hasConceptScore W2750451567C2775841333 @default.
• W2750451567 hasConceptScore W2750451567C2775850156 @default.
• W2750451567 hasConceptScore W2750451567C2777031167 @default.
• W2750451567 hasConceptScore W2750451567C2778394091 @default.
• W2750451567 hasConceptScore W2750451567C2779134260 @default.
• W2750451567 hasConceptScore W2750451567C2779483572 @default.
• W2750451567 hasConceptScore W2750451567C2984863031 @default.
• W2750451567 hasConceptScore W2750451567C541997718 @default.
• W2750451567 hasConceptScore W2750451567C71924100 @default.
• W2750451567 hasConceptScore W2750451567C84393581 @default.
• W2750451567 hasIssue "2" @default.
• W2750451567 hasLocation W27504515671 @default.
• W2750451567 hasLocation W27504515672 @default.

• next