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- W2750463187 abstract "We describe here an alternative method to prepare bis(2-pyridyl) diselenide derivatives using reduced selenium species, generated in situ, and different 2-chloropyridines promoted by p-TSOH in PEG-400 as solvent. This is a straightforward protocol to prepare bis(3-amino-2-pyridyl) diselenides unprecedented to date. Still, this article describe the employment of synthesized bis(3-amino-2-pyridyl) diselenide and a diverse array of aryl aldehydes to afford the corresponding 2-aryl-selenazolo[5,4-b]pyridines in satisfactory yields and, in a short reaction time under basic condition. Furthermore, when the bis(3-amino-2-pyridyl) diselenide reacted with aliphatic halides, in the presence of NaBH4, a wide range of unsymmetrical diorganyl selenides was obtained. To complete this investigation the bis(3-amino-2-pyridyl) diselenide was evaluated for its inhibitory effect on the acetylcholinesterase (AChE) activity and free radical-scavenging capacity. Results demonstrated that this compound was antioxidant and inhibitor of the AChE activity, being a promising therapeutic agent for the treatment of Alzheimer’s disease and other neurodegenerative disorders." @default.
- W2750463187 created "2017-08-31" @default.
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- W2750463187 date "2017-09-01" @default.
- W2750463187 modified "2023-10-16" @default.
- W2750463187 title "Preparation of bis(2-pyridyl) diselenide derivatives: Synthesis of selenazolo[5,4-b]pyridines and unsymmetrical diorganyl selenides, and evaluation of antioxidant and anticholinesterasic activities" @default.
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- W2750463187 doi "https://doi.org/10.1016/j.tetlet.2017.08.030" @default.
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